Featured Research

from universities, journals, and other organizations

Using microbubbles to improve cancer therapy

Date:
April 25, 2013
Source:
BioMed Central Limited
Summary:
Microbubbles decrease the time and acoustic power of ultrasound required to heat and destroy an embedded target, finds new research. If these results can be replicated in the clinic, microbubbles could improve the efficiency of high intensity ultrasound treatment of solid tumors.

Microbubbles decrease the time and acoustic power of ultrasound required to heat and destroy an embedded target, finds research in BioMed Central's open access journal Journal of Therapeutic Ultrasound. If these results can be replicated in the clinic, microbubbles could improve the efficiency of high intensity ultrasound treatment of solid tumors.

High intensity ultrasound is already used to treat solid tumors. Ultrasound can be focused through soft tissue and, because it does not require probes or surgery, is non-invasive. However if the tumor is behind the ribcage or skull, the bone absorbs some of the ultrasound. Consequently the length of treatment needs to be increased, plus there is a potential for heat damage to the bone.

In order to improve ultrasound therapy, especially in these difficult to treat cases, a team from Boston University has developed phase shift nanoemulsions (PSNE), which produce tiny microbubbles when blasted with high intensity ultrasound. Microbubbles smaller than 200nm passively accumulate in tumors and this study shows that microbubbles of this size can amplify the effects of ultrasound in hydrogels designed to mimic solid tumors inside the body.

Holes formed in a predictable manner and with a predictable shape which altered with acoustic intensity. The acoustic intensity and exposure time required for thermal destruction of tumor tissue were both reduced by more than half, compared to ultrasound without microbubbles. The lower power levels and time needed to destroy a target in the presence of microbubbles could potentially improve cancer therapy, especially in hard to reach areas.

The first stage in any new treatment is to show safety and efficacy. Prof Tyrone Porter, who led this study explained, "We used PSNE of phospholipid coated perfluorcarbon which have no known toxicity and have already be shown to be safe clinically. Our technique pushes forward the possible applications of ultrasound therapy in treating solid tumors."

Open access publisher BioMed Central is proud to announce the launch of Journal of Therapeutic Ultrasound in partnership with the Focused Ultrasound Foundation and the International Society for Therapeutic Ultrasound.

"Focused ultrasound technology has enormous potential to improve the quality of lives for millions around the world," noted Neal F. Kassell, M.D., Chairman and Founder of the Focused Ultrasound Foundation. "The research reported in the Journal of Therapeutic Ultrasound will be central to advancing the field and will help accelerate the progress of focused ultrasound towards clinical adoption."


Story Source:

The above story is based on materials provided by BioMed Central Limited. Note: Materials may be edited for content and length.


Journal Reference:

  1. Peng Zhang, Jonathan A Kopechek and Tyrone M Porter. The impact of vaporized nanoemulsions on ultrasound-mediated ablation. Journal of Therapeutic Ultrasound, 2013 DOI: 10.1186/2050-5736-1-2

Cite This Page:

BioMed Central Limited. "Using microbubbles to improve cancer therapy." ScienceDaily. ScienceDaily, 25 April 2013. <www.sciencedaily.com/releases/2013/04/130424222420.htm>.
BioMed Central Limited. (2013, April 25). Using microbubbles to improve cancer therapy. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2013/04/130424222420.htm
BioMed Central Limited. "Using microbubbles to improve cancer therapy." ScienceDaily. www.sciencedaily.com/releases/2013/04/130424222420.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins