Featured Research

from universities, journals, and other organizations

Using microbubbles to improve cancer therapy

Date:
April 25, 2013
Source:
BioMed Central Limited
Summary:
Microbubbles decrease the time and acoustic power of ultrasound required to heat and destroy an embedded target, finds new research. If these results can be replicated in the clinic, microbubbles could improve the efficiency of high intensity ultrasound treatment of solid tumors.

Microbubbles decrease the time and acoustic power of ultrasound required to heat and destroy an embedded target, finds research in BioMed Central's open access journal Journal of Therapeutic Ultrasound. If these results can be replicated in the clinic, microbubbles could improve the efficiency of high intensity ultrasound treatment of solid tumors.

Related Articles


High intensity ultrasound is already used to treat solid tumors. Ultrasound can be focused through soft tissue and, because it does not require probes or surgery, is non-invasive. However if the tumor is behind the ribcage or skull, the bone absorbs some of the ultrasound. Consequently the length of treatment needs to be increased, plus there is a potential for heat damage to the bone.

In order to improve ultrasound therapy, especially in these difficult to treat cases, a team from Boston University has developed phase shift nanoemulsions (PSNE), which produce tiny microbubbles when blasted with high intensity ultrasound. Microbubbles smaller than 200nm passively accumulate in tumors and this study shows that microbubbles of this size can amplify the effects of ultrasound in hydrogels designed to mimic solid tumors inside the body.

Holes formed in a predictable manner and with a predictable shape which altered with acoustic intensity. The acoustic intensity and exposure time required for thermal destruction of tumor tissue were both reduced by more than half, compared to ultrasound without microbubbles. The lower power levels and time needed to destroy a target in the presence of microbubbles could potentially improve cancer therapy, especially in hard to reach areas.

The first stage in any new treatment is to show safety and efficacy. Prof Tyrone Porter, who led this study explained, "We used PSNE of phospholipid coated perfluorcarbon which have no known toxicity and have already be shown to be safe clinically. Our technique pushes forward the possible applications of ultrasound therapy in treating solid tumors."

Open access publisher BioMed Central is proud to announce the launch of Journal of Therapeutic Ultrasound in partnership with the Focused Ultrasound Foundation and the International Society for Therapeutic Ultrasound.

"Focused ultrasound technology has enormous potential to improve the quality of lives for millions around the world," noted Neal F. Kassell, M.D., Chairman and Founder of the Focused Ultrasound Foundation. "The research reported in the Journal of Therapeutic Ultrasound will be central to advancing the field and will help accelerate the progress of focused ultrasound towards clinical adoption."


Story Source:

The above story is based on materials provided by BioMed Central Limited. Note: Materials may be edited for content and length.


Journal Reference:

  1. Peng Zhang, Jonathan A Kopechek and Tyrone M Porter. The impact of vaporized nanoemulsions on ultrasound-mediated ablation. Journal of Therapeutic Ultrasound, 2013 DOI: 10.1186/2050-5736-1-2

Cite This Page:

BioMed Central Limited. "Using microbubbles to improve cancer therapy." ScienceDaily. ScienceDaily, 25 April 2013. <www.sciencedaily.com/releases/2013/04/130424222420.htm>.
BioMed Central Limited. (2013, April 25). Using microbubbles to improve cancer therapy. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2013/04/130424222420.htm
BioMed Central Limited. "Using microbubbles to improve cancer therapy." ScienceDaily. www.sciencedaily.com/releases/2013/04/130424222420.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins