Featured Research

from universities, journals, and other organizations

Discovery may lead to new treatments for jaundice

Date:
June 10, 2013
Source:
University of Guelph
Summary:
Helping to protect newborns and older patients against more severe effects of jaundice is the hope of researchers who have shown how a liver enzyme protects cells from damage caused by the condition. Their discovery might ultimately lead to an alternative treatment for jaundice, such as a new drug or supplement.

Helping to protect newborns and older patients against more severe effects of jaundice is the hope of University of Guelph researchers, who have shown how a liver enzyme protects cells from damage caused by the condition.

Related Articles


Their discovery might ultimately lead to an alternative treatment for jaundice, such as a new drug or supplement, says Daniel Kim, a research technician in Guelph's Department of Biomedical Sciences.

He is lead author of a paper published recently in the journal Toxicology and Applied Pharmacology. Co-authors are biomedical sciences professor Gordon Kirby, former research associate Monica Antenos, and Prof. Jim Squires of U of G's Department of Animal and Poultry Science.

Almost two out of three newborns contract jaundice, with its telltale skin yellowing. Normal treatment involves use of ultraviolet light. UV treatment doesn't always work.

Although the condition is usually benign, severe cases can cause permanent brain damage and lead to cerebral palsy and hearing loss.

Jaundice can also affect people with liver disease or increased breakdown of red blood cells, as in malaria.

In all cases, a substance called bilirubin collects in the blood. High amounts can be toxic and can cause permanent brain damage, said Kirby.

Other researchers had already found a naturally occurring enzyme that breaks down bilirubin. Called cytochrome P450 2A5, the enzyme is known to increase in people with liver ailments.

The Guelph team has shown that more bilirubin in the blood activates the gene to make this enzyme. The enzyme helps remove bilirubin and prevents liver cells from dying, said Kirby.

The U of G researchers used cultured liver cells from mice for their study.

Scientists need to determine safe and effective levels of the enzyme before developing any treatment, said Kirby.

"We need to fine-tune our ability to manipulate this enzyme and fully understand its role in bilirubin removal," he said. Kirby has long studied the enzyme's role in nicotine addiction in smokers.


Story Source:

The above story is based on materials provided by University of Guelph. Note: Materials may be edited for content and length.


Cite This Page:

University of Guelph. "Discovery may lead to new treatments for jaundice." ScienceDaily. ScienceDaily, 10 June 2013. <www.sciencedaily.com/releases/2013/06/130610084314.htm>.
University of Guelph. (2013, June 10). Discovery may lead to new treatments for jaundice. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2013/06/130610084314.htm
University of Guelph. "Discovery may lead to new treatments for jaundice." ScienceDaily. www.sciencedaily.com/releases/2013/06/130610084314.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

Oxfam Calls for Massive Aid for Ebola-Hit West Africa

AFP (Jan. 29, 2015) Oxfam International has called for a multi-million dollar post-Ebola "Marshall Plan", with financial support given by wealthy countries, to help Guinea, Sierra Leone and Liberia to recover. Duration: 01:10 Video provided by AFP
Powered by NewsLook.com
Are We Winning The Fight Against Ebola?

Are We Winning The Fight Against Ebola?

Newsy (Jan. 29, 2015) The World Health Organization announced the fight against Ebola has entered its second phase as the number of cases per week has steadily dropped. Video provided by Newsy
Powered by NewsLook.com
Calif. Health Officials Campaign Against E-Cigarettes

Calif. Health Officials Campaign Against E-Cigarettes

Newsy (Jan. 29, 2015) The California Health Department says e-cigarettes are a public health risk for both smokers and those who inhale e-cig smoke secondhand. Video provided by Newsy
Powered by NewsLook.com
Measles Scare Sends 66 Calif. Students Home

Measles Scare Sends 66 Calif. Students Home

AP (Jan. 29, 2015) Officials say 66 students at a Southern California high school have been told to stay home through the end of next week because they may have been exposed to measles and are not vaccinated. (Jan. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins