Featured Research

from universities, journals, and other organizations

Discovery may lead to new treatments for jaundice

Date:
June 10, 2013
Source:
University of Guelph
Summary:
Helping to protect newborns and older patients against more severe effects of jaundice is the hope of researchers who have shown how a liver enzyme protects cells from damage caused by the condition. Their discovery might ultimately lead to an alternative treatment for jaundice, such as a new drug or supplement.

Helping to protect newborns and older patients against more severe effects of jaundice is the hope of University of Guelph researchers, who have shown how a liver enzyme protects cells from damage caused by the condition.

Related Articles


Their discovery might ultimately lead to an alternative treatment for jaundice, such as a new drug or supplement, says Daniel Kim, a research technician in Guelph's Department of Biomedical Sciences.

He is lead author of a paper published recently in the journal Toxicology and Applied Pharmacology. Co-authors are biomedical sciences professor Gordon Kirby, former research associate Monica Antenos, and Prof. Jim Squires of U of G's Department of Animal and Poultry Science.

Almost two out of three newborns contract jaundice, with its telltale skin yellowing. Normal treatment involves use of ultraviolet light. UV treatment doesn't always work.

Although the condition is usually benign, severe cases can cause permanent brain damage and lead to cerebral palsy and hearing loss.

Jaundice can also affect people with liver disease or increased breakdown of red blood cells, as in malaria.

In all cases, a substance called bilirubin collects in the blood. High amounts can be toxic and can cause permanent brain damage, said Kirby.

Other researchers had already found a naturally occurring enzyme that breaks down bilirubin. Called cytochrome P450 2A5, the enzyme is known to increase in people with liver ailments.

The Guelph team has shown that more bilirubin in the blood activates the gene to make this enzyme. The enzyme helps remove bilirubin and prevents liver cells from dying, said Kirby.

The U of G researchers used cultured liver cells from mice for their study.

Scientists need to determine safe and effective levels of the enzyme before developing any treatment, said Kirby.

"We need to fine-tune our ability to manipulate this enzyme and fully understand its role in bilirubin removal," he said. Kirby has long studied the enzyme's role in nicotine addiction in smokers.


Story Source:

The above story is based on materials provided by University of Guelph. Note: Materials may be edited for content and length.


Cite This Page:

University of Guelph. "Discovery may lead to new treatments for jaundice." ScienceDaily. ScienceDaily, 10 June 2013. <www.sciencedaily.com/releases/2013/06/130610084314.htm>.
University of Guelph. (2013, June 10). Discovery may lead to new treatments for jaundice. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2013/06/130610084314.htm
University of Guelph. "Discovery may lead to new treatments for jaundice." ScienceDaily. www.sciencedaily.com/releases/2013/06/130610084314.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins