Featured Research

from universities, journals, and other organizations

Insulin resistance linked to weaker bones

Date:
June 17, 2013
Source:
Endocrine Society
Summary:
Reduced effectiveness of the hormone insulin, or insulin resistance, is associated with weakened bones, a clinical study shows.

Reduced effectiveness of the hormone insulin, or insulin resistance, is associated with weakened bones, a clinical study shows.

The results were presented Sunday at The Endocrine Society's 95th Annual Meeting in San Francisco.

In the United States, the incidence of diabetes is quickly mounting. Between the years of 1980 and 2011, the number of cases diagnosed jumped from about 6 million to nearly 21 million, according to statistics from the Centers for Disease Control and Prevention.

Type 2 diabetes is the result of insulin resistance, which causes cells to react improperly to the insulin that is secreted. Normally, insulin helps regulate sugar, or glucose, concentrations in the blood. With insulin resistance, the pancreas produces increased amounts of the hormone to compensate. This leads to abnormally high levels of insulin in the blood, or hyperinsulinemia.

In turn, hyperinsulinemia increases the risk of other diseases. Left unchecked, it can cause high blood pressure, obesity and other serious complications. Together, these conditions are known as metabolic syndrome, which greatly increases the risk of heart disease and stroke.

In addition, type 2 diabetes is linked to a greater risk of bone fractures, even though bone-mineral density often is higher among diabetics, compared to non-diabetics. To assess the effects of insulin resistance on bone strength, researchers correlated bone strength relative to load with the level of insulin resistance.

They found that bone strength decreased by 10 to 14 percent every time insulin resistance doubled. This decrease in bone strength corresponded to high insulin levels in the blood, rather than high blood-sugar concentrations.

"This finding could have significant public health implications for the bone health of a large number of obese individuals, both those with and those without type 2 diabetes," said the study's lead author Preethi Srikanthan, MD, associate clinical professor at the University of California, Los Angeles. "Being obese not only increases your risk of being diabetic, but it also increases your risk for fragile bones."

Researchers assessed bone strength with a special X-ray test that measures bone-mineral density. They combined bone density with bone size and body height and weight to estimate bone strength relative to load. They then analyzed insulin resistance by measuring levels of sugar and insulin in blood samples, and correlated these data with the bone strength data, adjusted for age, sex, race and, for women, menopause transition status.

They obtained study data from 717 participants in a nationwide project called the Biomarker Project of the Midlife in the United States Study.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "Insulin resistance linked to weaker bones." ScienceDaily. ScienceDaily, 17 June 2013. <www.sciencedaily.com/releases/2013/06/130617110715.htm>.
Endocrine Society. (2013, June 17). Insulin resistance linked to weaker bones. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2013/06/130617110715.htm
Endocrine Society. "Insulin resistance linked to weaker bones." ScienceDaily. www.sciencedaily.com/releases/2013/06/130617110715.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins