Featured Research

from universities, journals, and other organizations

Vitamin D deficiency may raise allergy and asthma risk in obese children, teens

Date:
June 17, 2013
Source:
Endocrine Society
Summary:
One reason why obese children and teenagers are more likely to have hard-to-control asthma and allergies may be vitamin D deficiency, a new study finds.

One reason why obese children and teenagers are more likely to have hard-to-control asthma and allergies may be vitamin D deficiency, a new study finds. Results of the study will be presented Tuesday at The Endocrine Society's 95th Annual Meeting in San Francisco.

Related Articles


"The increased risk for asthma and allergies, and for more severe cases of allergic disease, in overweight and obese adolescents has not previously been understood," said Candace Percival, MD, lead investigator and a pediatric endocrinology fellow at Walter Reed National Military Medical Center, Bethesda, MD. "However, past research has shown that vitamin D is important for a normal immune system and that vitamin D deficiency is common in obese individuals."

The study, conducted in 86 subjects ages 10 to 18 years, aimed to determine whether vitamin D deficiency plays a role in the increased allergy risk in youth with excess weight.

Fifty-four study subjects were overweight or obese, as determined by their body mass index (BMI) being at or above the 85th percentile for their age and sex on growth charts. The remaining 32 subjects had a healthy weight. For each subject, the researchers calculated the BMI standard deviation, called the BMI Z-score. All subjects had a vitamin D blood test called serum 25-hydroxyvitamin D, and all obese subjects were vitamin D insufficient, Percival said.

She and her team also measured levels of certain hormones called adipokines that originate in fat cells. Specifically, they assessed leptin and adiponectin, which laboratory and animal studies have shown change with obesity, with leptin becoming elevated and adiponectin decreasing. They evaluated whether these two hormones correlate with vitamin D levels and, in some subjects, with the body's allergy signaling pathways -- biochemical measures of allergic disease.

A subgroup of 39 subjects (19 with overweight or obesity and 20 with a healthy weight) underwent blood tests to measure their levels of immunoglobulin E (IgE), which is one of the main players in allergic reactions. Of these 39 subjects, 36 (17 overweight/obese and 19 healthy-weight) also underwent measurements of chemical messengers called cytokines that contribute to allergy and asthma, specifically interleukins (IL) 4, 6, 10 and 13 and interferon-gamma.

The investigators found significant correlations between the severity of the subjects' obesity, the adipokine levels and some biochemical measures of allergic disease. As expected, the higher the BMI Z-score was (indicating greater obesity), the higher the level of leptin and the lower the levels of adiponectin and vitamin D, the authors reported. Obese subjects also had increased levels of IgE, IL-6 and IL-13. However, Percival said, "the relationship between the BMI-Z score and the adipokines and markers of allergic disease seemed to depend on the vitamin D deficiency seen in the more obese patients, leading us to conclude that the increased risk for allergy in obesity may be mediated by vitamin D to some degree."

"This is the first study, to our knowledge, that ties together the relationship of vitamin D deficiency and increased allergy risk and severity in obese and overweight adolescents," she said.

The study received funding from Walter Reed's Department of Research Programs and the Diabetes Action Research and Education Foundation in Washington, D.C.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "Vitamin D deficiency may raise allergy and asthma risk in obese children, teens." ScienceDaily. ScienceDaily, 17 June 2013. <www.sciencedaily.com/releases/2013/06/130617111128.htm>.
Endocrine Society. (2013, June 17). Vitamin D deficiency may raise allergy and asthma risk in obese children, teens. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2013/06/130617111128.htm
Endocrine Society. "Vitamin D deficiency may raise allergy and asthma risk in obese children, teens." ScienceDaily. www.sciencedaily.com/releases/2013/06/130617111128.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins