Featured Research

from universities, journals, and other organizations

Researchers find zinc's crucial pathway to the brain

Date:
June 26, 2013
Source:
Marine Biological Laboratory
Summary:
A new study helps explain how parts of the brain maintain their delicate balance of zinc, an element required in minute but crucial doses, particularly during embryonic development.

ZIP12 RNA marked with blue dye in a frog brain.
Credit: Image courtesy of Marine Biological Laboratory

A new study helps explain how parts of the brain maintain their delicate balance of zinc, an element required in minute but crucial doses, particularly during embryonic development.

The study, led at the Marine Biological Laboratory (MBL) by Mark Messerli in collaboration with scientists from the University of California, Davis, shows that neural cells require zinc uptake through a membrane transporter referred to as ZIP12.. If that route is closed, neuronal sprouting and growth are significantly impaired and is fatal for a developing embryo. Their discovery was published in the Proceedings of the National Academy of Sciences.

"This particular transporter is an essential doorway for many neurons in the central nervous system," explains Messerli. "You knock out this one gene, this one particular pathway for the uptake of zinc into these cells, and you essentially prevent neuronal outgrowth. That's lethal to the embryo."

Previously, scientists thought that zinc could use more than one pathway to enter the cell during early brain development. Some other elements, like calcium, enjoy such luxury of multiple options.

Knocking out ZIP12, affected several critical processes in the brain, the scientists found. For example, frog embryos were unable to develop their neural systems properly. Additionally, neurons had trouble reaching out to connect to other neurons; their extensions were both shorter and fewer in number than normal.

"We were surprised that ZIP12 was required at such an early and critical stage of development," said Winyoo Chowanadisai, a researcher in nutrition at the University of California at Davis and visiting scientist in the Cellular Dynamics Program at the MBL. Dr. Chowanadisai was the first on the team to realize that ZIP12 is expressed in such abundance in the brain."This study also reinforces the importance of periconceptional and prenatal nutrition and counseling to promote health during the earliest stages of life."

ZIP12 is part of a larger family of transporters involved in the movement of metal ions from outside the cell. Other reports showed that simultaneously blocking 3 other transporters in the family -- including ZIP1, 2, and 3 -- had no major effects on embryonic development.

Zinc is needed for healthy neural development, helping the brain to learn and remember new information. However, too much zinc can also be problematic.

The research team is investigating the implications of their results on processes like embryonic brain development and wound healing.

"[The result] was not expected," said Messerli, a physiologist in the MBL's Bell Center for Regenerative Biology and Tissue Enginering and Cellular Dynamics Program. ""We found that zinc uptake through ZIP12 is a regulatory point for neuronal growth, required for development and possibly required for learning and memory throughout life. We want to elucidate the downstream targets that zinc is affecting. That's the next exploration."


Story Source:

The above story is based on materials provided by Marine Biological Laboratory. The original article was written by Aviva Hope Rutkin. Note: Materials may be edited for content and length.


Journal Reference:

  1. W. Chowanadisai, D. M. Graham, C. L. Keen, R. B. Rucker, M. A. Messerli. Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12). Proceedings of the National Academy of Sciences, 2013; 110 (24): 9903 DOI: 10.1073/pnas.1222142110

Cite This Page:

Marine Biological Laboratory. "Researchers find zinc's crucial pathway to the brain." ScienceDaily. ScienceDaily, 26 June 2013. <www.sciencedaily.com/releases/2013/06/130626162822.htm>.
Marine Biological Laboratory. (2013, June 26). Researchers find zinc's crucial pathway to the brain. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2013/06/130626162822.htm
Marine Biological Laboratory. "Researchers find zinc's crucial pathway to the brain." ScienceDaily. www.sciencedaily.com/releases/2013/06/130626162822.htm (accessed September 23, 2014).

Share This



More Plants & Animals News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Ice Age Wooly Mammoth Remains for Sale

Raw: Ice Age Wooly Mammoth Remains for Sale

AP (Sep. 23, 2014) A rare, well-preserved skeleton of a woolly mammoth is going on sale at Summers Place Auctions hope the 11.5-foot tall, almost intact specimen will fetch between $245,000 to $409,000. (Sept. 23) Video provided by AP
Powered by NewsLook.com
Fox Bites Conn. Student And School Staffers In Rare Attack

Fox Bites Conn. Student And School Staffers In Rare Attack

Newsy (Sep. 23, 2014) A fox attacked a second-grade boy at a Connecticut elementary school Monday. It also attacked two school staff members and a woman and her dog. Video provided by Newsy
Powered by NewsLook.com
Will Living Glue Be A Thing?

Will Living Glue Be A Thing?

Newsy (Sep. 23, 2014) Using proteins derived from mussels, engineers at MIT have made a supersticky underwater adhesive. They're now looking to make "living glue." Video provided by Newsy
Powered by NewsLook.com
Raw: Tiger Kills Man at India Zoo

Raw: Tiger Kills Man at India Zoo

AP (Sep. 23, 2014) A white tiger killed a young man who climbed over a fence at the New Delhi zoo and jumped into the animal's enclosure on Tuesday, a spokesman said. (Sept. 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins