Featured Research

from universities, journals, and other organizations

Discovery sheds light on why Alzheimer's drugs rarely help

Date:
July 1, 2013
Source:
University of California, Los Angeles (UCLA), Health Sciences
Summary:
New research reveals that the likely culprit behind Alzheimer's has a different molecular structure than current drugs' target -- perhaps explaining why current medications produce little improvement in patients.

Current Alzheimer's drugs target the amyloid fibers (on right), which have a vastly different molecular structure than amyloid oligomers (on left), the likely culprit behind the disease. The UCLA findings may shed light on why existing Alzheimer's drugs produce limited effect.
Credit: UCLA/Gao lab

The Alzheimer's Association projects that the number of people living with Alzheimer's disease will soar from 5 million to 13.8 million by 2050 unless scientists develop new ways to stop the disease. Current medications do not treat Alzheimer's or stop it from progressing; they only temporarily lessen symptoms, such as memory loss and confusion.

Related Articles


Current Alzheimer's drugs aim to reduce the amyloid plaques -- sticky deposits that build up in the brain--that are a visual trademark of the disease. The plaques are made of long fibers of a protein called Amyloid β, or Aβ. Recent studies, however, suggest that the real culprit behind Alzheimer's may be small Aβ clumps called oligomers that appear in the brain years before plaques develop.

In unraveling oligomers' molecular structure, UCLA scientists discovered that Aβ has a vastly different organization in oligomers than in amyloid plaques. Their finding could shed light on why Alzheimer's drugs designed to seek out amyloid plaques produce zero effect on oligomers.

The UCLA study suggests that recent experimental Alzheimer's drugs failed in clinical trials because they zero in on plaques and do not work on oligomers. Future studies on oligomers will help speed the development of new drugs specifically aiming at Aβ oligomers.

The study was published as Paper of the Week in the June 28 issue of the peer-reviewed Journal of Biological Chemistry.


Story Source:

The above story is based on materials provided by University of California, Los Angeles (UCLA), Health Sciences. Note: Materials may be edited for content and length.


Cite This Page:

University of California, Los Angeles (UCLA), Health Sciences. "Discovery sheds light on why Alzheimer's drugs rarely help." ScienceDaily. ScienceDaily, 1 July 2013. <www.sciencedaily.com/releases/2013/07/130701100602.htm>.
University of California, Los Angeles (UCLA), Health Sciences. (2013, July 1). Discovery sheds light on why Alzheimer's drugs rarely help. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2013/07/130701100602.htm
University of California, Los Angeles (UCLA), Health Sciences. "Discovery sheds light on why Alzheimer's drugs rarely help." ScienceDaily. www.sciencedaily.com/releases/2013/07/130701100602.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New FDA-Approved Diabetes Medicine Might Save Drugmaker

New FDA-Approved Diabetes Medicine Might Save Drugmaker

Newsy (Feb. 26, 2015) The U.S. Food and Drug Administration approved new diabetes drug Toujeo on Wednesday, a move that might save French drugmaker Sanofi&apos;s profits. Video provided by Newsy
Powered by NewsLook.com
The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com
The 5 Best Tips to Look Younger Now

The 5 Best Tips to Look Younger Now

Buzz60 (Feb. 26, 2015) Life happens, and we all get older, but forget the pricey anti-aging products and plastic surgery. You can tweak your habits to turn back the hands of time. Krystin Goodwin (@krystingoodwin) has a few simple tips to help you look and feel younger. Video provided by Buzz60
Powered by NewsLook.com
Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins