Featured Research

from universities, journals, and other organizations

Sugar makes cancer light-up in MRI scanners

Date:
July 7, 2013
Source:
University College London - UCL
Summary:
A new technique for detecting cancer by imaging the consumption of sugar with magnetic resonance imaging (MRI) has been unveiled. The breakthrough could provide a safer and simpler alternative to standard radioactive techniques and enable radiologists to image tumors in greater detail.

Tumors use large quantities of glucose to sustain their growth. By injecting normal, unlabeled sugar, UCL scientists have developed a way to detect its accumulation in tumors using magnetic resonance imaging.
Credit: Credit UCL

A new technique for detecting cancer by imaging the consumption of sugar with magnetic resonance imaging (MRI) has been unveiled by UCL scientists. The breakthrough could provide a safer and simpler alternative to standard radioactive techniques and enable radiologists to image tumours in greater detail.

Related Articles


The new technique, called 'glucose chemical exchange saturation transfer' (glucoCEST), is based on the fact that tumours consume much more glucose (a type of sugar) than normal, healthy tissues in order to sustain their growth.

The researchers found that sensitising an MRI scanner to glucose uptake caused tumours to appear as bright images on MRI scans of mice.

Lead researcher Dr Simon Walker-Samuel, from the UCL Centre for Advanced Biomedical Imaging (CABI) said: "GlucoCEST uses radio waves to magnetically label glucose in the body. This can then be detected in tumours using conventional MRI techniques. The method uses an injection of normal sugar and could offer a cheap, safe alternative to existing methods for detecting tumours, which require the injection of radioactive material."

Professor Mark Lythgoe, Director of CABI and a senior author on the study, said: "We can detect cancer using the same sugar content found in half a standard sized chocolate bar. Our research reveals a useful and cost-effective method for imaging cancers using MRI -- a standard imaging technology available in many large hospitals."

He continued: "In the future, patients could potentially be scanned in local hospitals, rather than being referred to specialist medical centres."

The study is published in the journal Nature Medicine and trials are now underway to detect glucose in human cancers.

According to UCL's Professor Xavier Golay, another senior author on the study: "Our cross-disciplinary research could allow vulnerable patient groups such as pregnant women and young children to be scanned more regularly, without the risks associated with a dose of radiation."

Dr Walker-Samuel added: "We have developed a new state-of-the-art imaging technique to visualise and map the location of tumours that will hopefully enable us to assess the efficacy of novel cancer therapies."

The work was supported by public and charitable funding from the National Institute for Health Research University College London Hospitals Biomedical Research Centre, Cancer Research UK, Engineering and Physical Sciences Research Council (EPSRC) and the British Heart Foundation (BHF).


Story Source:

The above story is based on materials provided by University College London - UCL. Note: Materials may be edited for content and length.


Journal Reference:

  1. Simon Walker-Samuel, Rajiv Ramasawmy, Francisco Torrealdea, Marilena Rega, Vineeth Rajkumar, S Peter Johnson, Simon Richardson, Miguel Gon็alves, Harold G Parkes, Erik ลrstad, David L Thomas, R Barbara Pedley, Mark F Lythgoe, Xavier Golay. In vivo imaging of glucose uptake and metabolism in tumors. Nature Medicine, 2013; DOI: 10.1038/nm.3252

Cite This Page:

University College London - UCL. "Sugar makes cancer light-up in MRI scanners." ScienceDaily. ScienceDaily, 7 July 2013. <www.sciencedaily.com/releases/2013/07/130707162759.htm>.
University College London - UCL. (2013, July 7). Sugar makes cancer light-up in MRI scanners. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2013/07/130707162759.htm
University College London - UCL. "Sugar makes cancer light-up in MRI scanners." ScienceDaily. www.sciencedaily.com/releases/2013/07/130707162759.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Din้ Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins