Featured Research

from universities, journals, and other organizations

Scientists successfully generate 'artificial bones' from umbilical cord stem cells

Date:
July 18, 2013
Source:
University of Granada
Summary:
Researchers have patented a new biomaterial based on an activated carbon cloth support that acts as scaffolding for the construction of cells capable of bone regeneration. Although their results were obtained ex vivo, in the future they could help manufacture medicines to treat neoplastic, traumatic or degenerative bone pathologies. After obtaining artificial bone in the laboratory, the next step is to implant the biomaterial in animals to see if it can regenerate bone in them.

'Artificial bone', or mineralization of the extracellular matrix obtained by the Granada-based scientists thanks to their patent.
Credit: Image courtesy of University of Granada

Granada-based researchers patent a new biomaterial based on an activated carbon cloth support that acts as scaffolding for the construction of cells capable of bone regeneration. Although their results were obtained ‘ex vivo’, in the future they could help manufacture medicines to treat neoplastic, traumatic or degenerative bone pathologies. After obtaining artificial bone in the laboratory, the next step is to implant the biomaterial in animals to see if it can regenerate bone in them.

Scientists in Granada, Spain, have patented a new biomaterial that facilitates generating bone tissue—artificial bones in other words—from umbilical cord stem cells . The material, consisting of an activated carbon cloth support for cells that differentiate giving rise to a product that can promote bone growth, has recently been presented at a press conference at the Biomedical Research Centre, Granada.

Although the method has not yet been applied with ‘in vivo’ models, laboratory results are highly promising. In the future, they could help manufacture medicines for the repair of bone or osteochondrial, tumour or traumatic lesions and to replace lost cartilage in limbs. After obtaining artificial bones in the laboratory, the researchers' next step is to implant this biomaterial in experimental animal models—like rats or rabbits—to see if it can regenerate bone in them.

The scientists, from the Biomedical Research Centre and the Faculties of Sciences of the Universities of Granada and Jaén, and the Spanish National Research Council Institute of Parasitology and Biomedicine "López Neyra", have made this important scientific breakthrough after years of research in cell biology [1], radiobiology [2] and materials studies [3, 4].

Ground-breaking, worldwide scientific advance

As the authors of the patent explain, no alternative materials are currently available on the market, nor have any been described in the literature. Precedents exist in the development of materials that fulfil the basic function of stimulating cell differentiation but a biologically complex material similar to bone tissue has never before been produced “ex vivo”.

What's more, the method of stem cell differentiation developed in Granada uses a three-dimensional support and facilitates obtaining cell types implicated in bone regeneration in cell culture conditions not requiring additional differentiation factors or factors that differ from those present in the cell culture serum. In other words, thanks to this invention, a biomaterial consisting of stem cells supported on activated carbon cloth and capable of generating a product in which osteochondrial and mineralized extracellular organic matrix lineage cells exist, can be obtained.

The patent developed in Granada could have numerous applications in stem cell use in regenerative medicine, as well as in treating bone tissue and cartilage lesion problems.

Following this important scientific finding, the researchers are confident of obtaining the finance needed to be able to continue this work and achieve the ultimate objective of their invention: to regenerate bones by implanting biomaterial in patients with pathologies affecting the osseous system.


Story Source:

The above story is based on materials provided by University of Granada. Note: Materials may be edited for content and length.


Cite This Page:

University of Granada. "Scientists successfully generate 'artificial bones' from umbilical cord stem cells." ScienceDaily. ScienceDaily, 18 July 2013. <www.sciencedaily.com/releases/2013/07/130718101056.htm>.
University of Granada. (2013, July 18). Scientists successfully generate 'artificial bones' from umbilical cord stem cells. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2013/07/130718101056.htm
University of Granada. "Scientists successfully generate 'artificial bones' from umbilical cord stem cells." ScienceDaily. www.sciencedaily.com/releases/2013/07/130718101056.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) — Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) — Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com
House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) — The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Uganda on Alert for Ebola but No Confirmed Cases

Uganda on Alert for Ebola but No Confirmed Cases

AFP (July 31, 2014) — Uganda's health minister said on Thursday that there are no confirmed cases of Ebola in the country, but that it remained on alert for cases of the deadly virus. Uganda has suffered Ebola outbreaks in the past, most recently in 2012. Duration: 00:59 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins