Featured Research

from universities, journals, and other organizations

Environmental impact on mouse strains used for disease models

Date:
July 30, 2013
Source:
Sanford Health
Summary:
A study addresses how location and sex can affect mouse models in scientific research.

A study addressing how location and sex can affect mouse models in scientific research authored by Sanford Research's David Pearce, PhD, appears in July's issue of Scientific Reports.

Related Articles


"Location- and sex-specific differences in weight and motor coordination in two commonly used mouse strains" focuses on the migration of Pearce's mouse colony from the University of Rochester (NY) to Sioux Falls after his move to Sanford Research in 2009. Pearce found the shift in environment caused changes in the weight, motor coordination and motor learning capability of mice. Additionally, those changes also varied between male and female mice.

Differences between Rochester and Sioux Falls included, for example, diet and slightly adjusted testing protocols. In general, the mice in Sioux Falls were heavier and slower than those in Rochester. Pearce's study reveals why scientists performing the same mouse-model research in two different labs may experience different outcomes.

"We have long thought that environmental factors can have an effect on behavioral experiments, which has caused us to wonder how well we can reproduce experiments in different settings," said Pearce, Sanford Research's vice president and chief operating officer. "In our move from Rochester to Sioux Falls, we found that many factors, including local diets and handling procedures, had a significant influence on how our mice models reacted."


Story Source:

The above story is based on materials provided by Sanford Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Attila D. Kovács, David A. Pearce. Location- and sex-specific differences in weight and motor coordination in two commonly used mouse strains. Scientific Reports, 2013; 3 DOI: 10.1038/srep02116

Cite This Page:

Sanford Health. "Environmental impact on mouse strains used for disease models." ScienceDaily. ScienceDaily, 30 July 2013. <www.sciencedaily.com/releases/2013/07/130730163107.htm>.
Sanford Health. (2013, July 30). Environmental impact on mouse strains used for disease models. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2013/07/130730163107.htm
Sanford Health. "Environmental impact on mouse strains used for disease models." ScienceDaily. www.sciencedaily.com/releases/2013/07/130730163107.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) — The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) — Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins