Featured Research

from universities, journals, and other organizations

What causes a small, benign polyp to develop into severe invasive bladder cancer?

Date:
August 1, 2013
Source:
University of Plymouth
Summary:
Researchers have for the first time identified the mechanism that causes a small, benign polyp to develop into severe invasive bladder cancer.

Bladder cancer is a common condition -- an estimated 10,000 people are diagnosed with the disease each year in the UK. It is the seventh most common cancer in the UK, affecting men more than women.

Related Articles


Some people develop invasive bladder cancer, which is where the cancer has grown through the muscle layer of the bladder. When this occurs, there is a higher risk that the cancer will spread to other areas of the body and it is much more difficult to treat.

Until now the signalling process that allows a benign, small polyp to develop into something that spreads and is invasive has not been clear. But research carried out by a team at Plymouth University has for the first identified an important mechanism behind this process.

The research is published Aug. 1, 2013 in the American Journal of Physiology -- Renal Physiology.

Key to the research is a protein, pancreatic secretory trypsin inhibitor (PSTI), which is present in most bladder cancers. The research has identified the role PSTI plays in the signalling process that allows the spread and invasion of bladder cancer.

By understanding the process by which this protein helps the cells to spread, and invade into other tissue, researchers can start to develop ways to interrupt this process, potentially leading to new treatments.. This has the potential to improve the survival and life quality of those with early diagnosed bladder cancer, and reduce the instances where rigorous drug regimes or invasive surgery are required.

The research was led by Professor Raymond Playford and Dr. Tanya Marchbank from Plymouth University. Professor Playford said: "Although bladder cancer can be readily treated if caught early enough, once it starts to invade into deeper tissues and spread to distant sites it is a much more difficult, painful and life-affecting cancer to live with. Treatment becomes more difficult as tumours grow deeper into the bladder wall and spread, and survival rates decline -- it is estimated that just 25 per cent of those with severe invasive bladder cancer will be alive and well three years after diagnosis and treatment. By identifying the mechanism by which bladder cancer develops and spreads, we hope that in time therapies that manipulate this mechanism may be developed to improve the quality of life and survival rates of those with invasive bladder cancer."


Story Source:

The above story is based on materials provided by University of Plymouth. Note: Materials may be edited for content and length.


Cite This Page:

University of Plymouth. "What causes a small, benign polyp to develop into severe invasive bladder cancer?." ScienceDaily. ScienceDaily, 1 August 2013. <www.sciencedaily.com/releases/2013/08/130801095503.htm>.
University of Plymouth. (2013, August 1). What causes a small, benign polyp to develop into severe invasive bladder cancer?. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2013/08/130801095503.htm
University of Plymouth. "What causes a small, benign polyp to develop into severe invasive bladder cancer?." ScienceDaily. www.sciencedaily.com/releases/2013/08/130801095503.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins