Featured Research

from universities, journals, and other organizations

Researchers find home of best stem cells for bone marrow transplants

Date:
August 1, 2013
Source:
McMaster University
Summary:
Researchers have revealed the location of human blood stem cells that may improve bone marrow transplants. The best stem cells are at the ends of the bone.

McMaster University researchers have revealed the location of human blood stem cells that may improve bone marrow transplants. The best stem cells are at the ends of the bone.

It is hoped this discovery will lead to lowering the amount of bone marrow needed for a donation while increasing regeneration and lessening rejection in the recipient patients, says principal investigator Mick Bhatia, professor and scientific director of the McMaster Stem Cell and Cancer Research Institute.

In a paper published online today by the journal Cell Stem Cell, his team reports that human stem cells (HSC) residing in the end (trabecular region) of the bones display the highest regenerative ability of the blood and immune system.

"Like the best professional hockey players, our findings indicate blood stem cells are not all equal," said Bhatia. "We now reveal the reason why -- it's not the players themselves, but the effect the arena has on them that makes them the highest scorers."

Bone marrow transplants have been done for more than 50 years and are routine in most hospitals, providing a life saving treatment for cancer and other diseases including leukemia, anemia, and immune disorders.

Bhatia, who also holds a Canada Research Chair in Human Stem Cell Biology, said that cells surrounding the best blood stem cells are critically important, as these "stem cell neighbors" at the end of the bone provide the unique instructions that give these human blood stem cells their superior regenerative abilities.

The research was funded by the Canadian Institutes of Health Research and Ontario Cancer Research Institute.


Story Source:

The above story is based on materials provided by McMaster University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Borhane Guezguez, ClintonJ.V. Campbell, AllisonL. Boyd, Francis Karanu, FannyL. Casado, Christine DiCresce, TonyJ. Collins, Zoya Shapovalova, Anargyros Xenocostas, Mickie Bhatia. Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs. Cell Stem Cell, 2013; 13 (2): 175 DOI: 10.1016/j.stem.2013.06.015

Cite This Page:

McMaster University. "Researchers find home of best stem cells for bone marrow transplants." ScienceDaily. ScienceDaily, 1 August 2013. <www.sciencedaily.com/releases/2013/08/130801125018.htm>.
McMaster University. (2013, August 1). Researchers find home of best stem cells for bone marrow transplants. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2013/08/130801125018.htm
McMaster University. "Researchers find home of best stem cells for bone marrow transplants." ScienceDaily. www.sciencedaily.com/releases/2013/08/130801125018.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins