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New treatment for brittle bone disease found

Date:
August 9, 2013
Source:
University of Sheffield
Summary:
A new treatment for children with brittle bone disease has been developed.
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A new treatment for children with brittle bone disease has been developed by the University of Sheffield and Sheffield Children's Hospital.

The study of the new treatment for children with the fragile bone disease Osteogenesis Imperfecta was published this week in The Lancet.

This is the first study to clearly demonstrate that the use of the medicine risedronate can not only reduce the risk of fracture in children with brittle bones but also have rapid action -- the curves for fracture risk begin to diverge after only 6 weeks of treatment.

Nick Bishop, Professor of Paediatric Bone Disease at the University of Sheffield, said: "We wanted to show that the use of risedronate could significantly impact on children's lives by reducing fracture rates -- and it did.

"The fact that this medicine can be given by mouth at home (other similar medicines are given by a drip in hospital) makes it family-friendly."

The study, funded by the Alliance for Better Bone Health, trialled children with Osteogenesis Imperfecta aged 4-15 years and showed that oral risedronate reduced the risk of first and recurrent clinical fractures and that the drug was generally well tolerated.


Story Source:

The above post is reprinted from materials provided by University of Sheffield. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nick Bishop, Silvano Adami, S Faisal Ahmed, Jordi Antón, Paul Arundel, Christine P Burren, Jean-Pierre Devogelaer, Thomas Hangartner, Eva Hosszú, Joseph M Lane, Roman Lorenc, Outi Mäkitie, Craig F Munns, Ana Paredes, Helene Pavlov, Horacio Plotkin, Cathleen L Raggio, Maria Loreto Reyes, Eckhard Schoenau, Oliver Semler, David O Sillence, Robert D Steiner. Risedronate in children with osteogenesis imperfecta: a randomised, double-blind, placebo-controlled trial. The Lancet, 2013; DOI: 10.1016/S0140-6736(13)61091-0

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University of Sheffield. "New treatment for brittle bone disease found." ScienceDaily. ScienceDaily, 9 August 2013. <www.sciencedaily.com/releases/2013/08/130809115054.htm>.
University of Sheffield. (2013, August 9). New treatment for brittle bone disease found. ScienceDaily. Retrieved September 4, 2015 from www.sciencedaily.com/releases/2013/08/130809115054.htm
University of Sheffield. "New treatment for brittle bone disease found." ScienceDaily. www.sciencedaily.com/releases/2013/08/130809115054.htm (accessed September 4, 2015).

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