Featured Research

from universities, journals, and other organizations

Infection during newborn's first week of life associated with bacterial infection in the mother

Date:
August 20, 2013
Source:
Public Library of Science
Summary:
Early-onset neonatal infection, defined as infection in the first 7 days of life, is associated with maternal infection and colonization, according to a systematic review and meta-analysis.

Infection during a newborn's first 7 days of life is associated with bacterial infection or colonization in the mother

Early-onset neonatal infection, defined as infection in the first 7 days of life, is associated with maternal infection and colonization, a systematic review and meta-analysis by Grace Chan (Johns Hopkins School of Public Health) and colleagues found in this week's issue of PLOS Medicine.

Newborns of mothers with laboratory-confirmed infection had an odds ratio of 6.6 (95%CI 3.9-11.2) for laboratory-confirmed infection themselves compared with newborns of mothers without laboratory-confirmed infection. Newborns of mothers with colonization had an odds ratio of 9.4 (95%CI 3.1-28.5) of laboratory-confirmed infection compared with newborns of non-colonized mothers. Furthermore, newborns of mothers with risk factors for infection (prelabour rupture of membranes, preterm <37 weeks prelabour rupture of membranes, and prolonged rupture of membranes) had an odds ratio of infection of 2.3 (95%CI 1.0-5.4) compared with newborns of mothers without risk factors.

The authors searched medical literature databases through March 2013 for studies meeting their criteria, conducted hand searches, and had two researchers independently identify studies for inclusion. Two researchers also independently assessed study quality. They identified 448 full-text articles of which 83 studies met the criteria to be included in their study and 67 were able to be combined in meta-analyses.

According to the authors, past reviews have evaluated the effect of antibiotics for maternal Group B streptococcal colonization and maternal risk factors of infection on neonatal sepsis, but have not assessed the risks of infection and colonization for other bacterial types. The authors specifically excluded studies of nonbacterial infections, tetanus infections, sexually transmitted infections such as chlamydia or other TORCH (Toxoplasmosis, Rubella, Cytomegalovirus, Herpes simplex, Syphilis) infections, because they have different mechanisms of transmission. Limitations of the systematic review included heterogeneity and high or unclear risk of bias of the included studies.

Discussing the study's implications, the authors state, "The risk of early neonatal infection among women with maternal infections is high and presumably even higher in low-resource settings where most women deliver at home without access to health care. Intrapartum antibiotic prophylaxis could reduce the incidence of maternally acquired early-onset neonatal infections…Development of a simple algorithm that combines clinical signs and risk factors to diagnose maternal infections would be useful in settings where lab facilities (culture or colonization) are not available."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chan GJ, Lee AC, Baqui AH, Tan J, Black RE. Risk of Early-Onset Neonatal Infection with Maternal Infection or Colonization: A Global Systematic Review and Meta-Analysis. PLoS Med, 2013 DOI: 10.1371/journal.pmed.1001502

Cite This Page:

Public Library of Science. "Infection during newborn's first week of life associated with bacterial infection in the mother." ScienceDaily. ScienceDaily, 20 August 2013. <www.sciencedaily.com/releases/2013/08/130820185652.htm>.
Public Library of Science. (2013, August 20). Infection during newborn's first week of life associated with bacterial infection in the mother. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2013/08/130820185652.htm
Public Library of Science. "Infection during newborn's first week of life associated with bacterial infection in the mother." ScienceDaily. www.sciencedaily.com/releases/2013/08/130820185652.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins