Featured Research

from universities, journals, and other organizations

Combination of two imaging techniques allows new insights into brain function

Date:
August 25, 2013
Source:
Universitaet Tübingen
Summary:
The ability to measure brain functions non-invasively is important both for clinical diagnoses and research in neurology and psychology. Two main imaging techniques are used: positron emission tomography (PET), which reveals metabolic processes in the brain; and activity of different brain regions is measured on the basis of the cells’ oxygen consumption by magnetic resonance imaging (MRI). A direct comparison of PET and MRI measurements was previously difficult because each had to be performed in a separate machine. Scientists have now successfully combined both methods.

The ability to measure brain functions non-invasively is important both for clinical diagnoses and research in Neurology and Psychology. Two main imaging techniques are used: positron emission tomography (PET), which reveals metabolic processes in the brain; and activity of different brain regions is measured on the basis of the cells' oxygen consumption by magnetic resonance imaging (MRI). A direct comparison of PET and MRI measurements was previously difficult because each had to be performed in a separate machine.

Researchers from the Werner Siemens Imaging Center at the University of Tübingen under the direction of Professor Bernd J. Pichler in collaboration with the Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, and the Tübingen Max Planck Institute for Intelligent Systems have now successfully combined both methods. The researchers are able to explore functional processes in the brain in detail and can better assess what course of action to take. These results were achieved by the use of a PET insert enabling complementary, simultaneous PET/MRI scans. It was developed and built at the University of Tübingen.

The researchers could identify in certain regions a mismatch between glucose metabolism related brain activation measured with PET and oxygenation related signals, measured with MRI. Furthermore information about functional connectivity in the brain could be derived from MRI and from dynamic PET data. These results help to further decipher the nature of brain function, and are ultimately useful for basic research as well as clinical practice. The study, by lead author Dr. Hans Wehrl of Professor Bernd J. Pichler's research team is soon to be published in the journal Nature Medicine.

In PET imaging the distribution of a weakly radioactive substance is shown in cross sections of the body, enabling doctors to see many different metabolic and physiological functions at work. Functional MRI (fMRI) allows researchers to depict changes in blood oxygenation that are associated with brain function. This measurement of functional active brain regions is also important for the planning of brain surgeries, where particular care must be taken in certain areas. The ability to collect different kinds of data from different scans simultaneously represents a major step forward in the fields using these technologies.

This research was conducted in close cooperation with the companies Siemens and Bruker and was supported from the German Research Foundation (DFG), the Wilhelm Schuler Foundation and the Werner Siemens Foundation.


Story Source:

The above story is based on materials provided by Universitaet Tübingen. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hans F Wehrl, Mosaddek Hossain, Konrad Lankes, Chih-Chieh Liu, Ilja Bezrukov, Petros Martirosian, Fritz Schick, Gerald Reischl, Bernd J Pichler. Simultaneous PET-MRI reveals brain function in activated and resting state on metabolic, hemodynamic and multiple temporal scales. Nature Medicine, 2013; DOI: 10.1038/nm.3290

Cite This Page:

Universitaet Tübingen. "Combination of two imaging techniques allows new insights into brain function." ScienceDaily. ScienceDaily, 25 August 2013. <www.sciencedaily.com/releases/2013/08/130825171557.htm>.
Universitaet Tübingen. (2013, August 25). Combination of two imaging techniques allows new insights into brain function. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2013/08/130825171557.htm
Universitaet Tübingen. "Combination of two imaging techniques allows new insights into brain function." ScienceDaily. www.sciencedaily.com/releases/2013/08/130825171557.htm (accessed July 24, 2014).

Share This




More Matter & Energy News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Creative Makeovers for Ugly Cellphone Towers

Creative Makeovers for Ugly Cellphone Towers

AP (July 24, 2014) — Mobile phone companies and communities across the country are going to new lengths to disguise those unsightly cellphone towers. From a church bell tower to a flagpole, even a pencil, some towers are trying to make a point. (July 24) Video provided by AP
Powered by NewsLook.com
Robot Parking Valet Creates Stress-Free Travel

Robot Parking Valet Creates Stress-Free Travel

AP (July 23, 2014) — 'Ray' the robotic parking valet at Dusseldorf Airport in Germany lets travelers to avoid the hassle of finding a parking spot before heading to the check-in desk. (July 23) Video provided by AP
Powered by NewsLook.com
Boeing Ups Outlook on 52% Profit Jump

Boeing Ups Outlook on 52% Profit Jump

Reuters - Business Video Online (July 23, 2014) — Commercial aircraft deliveries rose seven percent at Boeing, prompting the aerospace company to boost full-year profit guidance- though quarterly revenues missed analyst estimates. Bobbi Rebell reports. Video provided by Reuters
Powered by NewsLook.com
Europe's Car Market on the Rebound?

Europe's Car Market on the Rebound?

Reuters - Business Video Online (July 23, 2014) — Daimler kicks off a round of second-quarter earnings results from Europe's top carmakers with a healthy set of numbers - prompting hopes that stronger sales in Europe will counter weakness in emerging markets. Hayley Platt reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins