Featured Research

from universities, journals, and other organizations

Impact of AF on stroke risk eliminated with multiple risk factors

Date:
August 31, 2013
Source:
European Society of Cardiology
Summary:
Patients with five or more risk factors have the same stroke risk as patients with atrial fibrillation, according to new research. The study included data on more than 4 million patients from Danish registries over a 10 year period.

Graph. The rate of stroke was calculated per 100 person-years.
Credit: Image courtesy of European Society of Cardiology

Patients with five or more risk factors have the same stroke risk as patients with atrial fibrillation, according to research presented at the ESC Congress today by Dr. Christine Benn Christiansen from Denmark. The study included data on more than 4 million patients from Danish registries over a 10 year period.

Dr Benn Christiansen said: "We know that atrial fibrillation increases the risk of ischemic stroke. And in patients with atrial fibrillation or previous ischemic stroke, the risk of stroke increases with the number of risk factors. But until now, little attention has been paid to the association between stroke risk and risk factors in patients without prior stroke or atrial fibrillation. We wanted to explore that association and to quantify if stroke risk was of comparable size in patients with numerous risk factors."

The study included 4,198,119 people aged 18 to 90 years with no history of stroke from nationwide Danish registries during 2000 to 2010. Of these, 161,651 (3.85%) had atrial fibrillation. The investigators compared the risk of stroke in patients with and without atrial fibrillation according to the number of risk factors.

The risk factors included in the study were myocardial infarction, peripheral artery disease, arterial embolism, excessive alcohol consumption, heart failure, carotid stenosis, retinal occlusion, chronic systemic inflammation, chronic kidney disease, venous thromboembolism, epilepsy, migraine, diabetes mellitus, hypertension and age >75 years.

The rate of stroke was calculated per 100 person-years. Patients with 0 risk factors and no atrial fibrillation had a stroke rate of 0.32 (95% confidence interval [CI] 0.31-0.32) per 100 person-years vs. 2.55 (CI=2.47-2.64) in patients with atrial fibrillation. With 1-2 risk factors present the stroke rate was 1.77 (CI=1.76-1.78) (no atrial fibrillation) and 5.69 (CI=5.61-5.78) (with atrial fibrillation).

For patients with 3-4 risk factors the stroke rates were 4.88 (CI=4.80-4.96) without atrial fibrillation vs. 6.96 (CI=6.79-7.14) with atrial fibrillation. In the presence of 5 or more risk factors stroke rates were 7.27 (CI=6.82-7.74) without atrial fibrillation vs. 8.00 (CI=7.34-8.71) with atrial fibrillation.

Dr Benn Christiansen said: "These results indicate that in patients with three or more risk factors, the risk of stroke is high regardless of the presence of atrial fibrillation. In fact, with five or more risk factors such as diabetes, hypertension, myocardial infarction, heart failure and age above 75 years, the risk associated with atrial fibrillation is eliminated."

She continued: "Our findings suggest that patients without atrial fibrillation or prior stroke may have a stroke risk that is comparable to patients with atrial fibrillation if they have three or more risk factors."

Dr Benn Christiansen concluded: "More research is needed on the effect of multiple risk factors on the risk of stroke in patients without atrial fibrillation. Stroke prevention measures may need to be tailored according to the number of risk factors."


Story Source:

The above story is based on materials provided by European Society of Cardiology. Note: Materials may be edited for content and length.


Cite This Page:

European Society of Cardiology. "Impact of AF on stroke risk eliminated with multiple risk factors." ScienceDaily. ScienceDaily, 31 August 2013. <www.sciencedaily.com/releases/2013/08/130831110917.htm>.
European Society of Cardiology. (2013, August 31). Impact of AF on stroke risk eliminated with multiple risk factors. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2013/08/130831110917.htm
European Society of Cardiology. "Impact of AF on stroke risk eliminated with multiple risk factors." ScienceDaily. www.sciencedaily.com/releases/2013/08/130831110917.htm (accessed September 16, 2014).

Share This



More Mind & Brain News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
'Magic Mushrooms' Could Help Smokers Quit

'Magic Mushrooms' Could Help Smokers Quit

Newsy (Sep. 11, 2014) In a small study, researchers found that the majority of long-time smokers quit after taking psilocybin pills and undergoing therapy sessions. Video provided by Newsy
Powered by NewsLook.com
'Fat Shaming' Might Actually Cause Weight Gain

'Fat Shaming' Might Actually Cause Weight Gain

Newsy (Sep. 11, 2014) A study for University College London suggests obese people who are discriminated against gain more weight than those who are not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins