Featured Research

from universities, journals, and other organizations

Impact of AF on stroke risk eliminated with multiple risk factors

Date:
August 31, 2013
Source:
European Society of Cardiology
Summary:
Patients with five or more risk factors have the same stroke risk as patients with atrial fibrillation, according to new research. The study included data on more than 4 million patients from Danish registries over a 10 year period.

Graph. The rate of stroke was calculated per 100 person-years.
Credit: Image courtesy of European Society of Cardiology

Patients with five or more risk factors have the same stroke risk as patients with atrial fibrillation, according to research presented at the ESC Congress today by Dr. Christine Benn Christiansen from Denmark. The study included data on more than 4 million patients from Danish registries over a 10 year period.

Dr Benn Christiansen said: "We know that atrial fibrillation increases the risk of ischemic stroke. And in patients with atrial fibrillation or previous ischemic stroke, the risk of stroke increases with the number of risk factors. But until now, little attention has been paid to the association between stroke risk and risk factors in patients without prior stroke or atrial fibrillation. We wanted to explore that association and to quantify if stroke risk was of comparable size in patients with numerous risk factors."

The study included 4,198,119 people aged 18 to 90 years with no history of stroke from nationwide Danish registries during 2000 to 2010. Of these, 161,651 (3.85%) had atrial fibrillation. The investigators compared the risk of stroke in patients with and without atrial fibrillation according to the number of risk factors.

The risk factors included in the study were myocardial infarction, peripheral artery disease, arterial embolism, excessive alcohol consumption, heart failure, carotid stenosis, retinal occlusion, chronic systemic inflammation, chronic kidney disease, venous thromboembolism, epilepsy, migraine, diabetes mellitus, hypertension and age >75 years.

The rate of stroke was calculated per 100 person-years. Patients with 0 risk factors and no atrial fibrillation had a stroke rate of 0.32 (95% confidence interval [CI] 0.31-0.32) per 100 person-years vs. 2.55 (CI=2.47-2.64) in patients with atrial fibrillation. With 1-2 risk factors present the stroke rate was 1.77 (CI=1.76-1.78) (no atrial fibrillation) and 5.69 (CI=5.61-5.78) (with atrial fibrillation).

For patients with 3-4 risk factors the stroke rates were 4.88 (CI=4.80-4.96) without atrial fibrillation vs. 6.96 (CI=6.79-7.14) with atrial fibrillation. In the presence of 5 or more risk factors stroke rates were 7.27 (CI=6.82-7.74) without atrial fibrillation vs. 8.00 (CI=7.34-8.71) with atrial fibrillation.

Dr Benn Christiansen said: "These results indicate that in patients with three or more risk factors, the risk of stroke is high regardless of the presence of atrial fibrillation. In fact, with five or more risk factors such as diabetes, hypertension, myocardial infarction, heart failure and age above 75 years, the risk associated with atrial fibrillation is eliminated."

She continued: "Our findings suggest that patients without atrial fibrillation or prior stroke may have a stroke risk that is comparable to patients with atrial fibrillation if they have three or more risk factors."

Dr Benn Christiansen concluded: "More research is needed on the effect of multiple risk factors on the risk of stroke in patients without atrial fibrillation. Stroke prevention measures may need to be tailored according to the number of risk factors."


Story Source:

The above story is based on materials provided by European Society of Cardiology. Note: Materials may be edited for content and length.


Cite This Page:

European Society of Cardiology. "Impact of AF on stroke risk eliminated with multiple risk factors." ScienceDaily. ScienceDaily, 31 August 2013. <www.sciencedaily.com/releases/2013/08/130831110917.htm>.
European Society of Cardiology. (2013, August 31). Impact of AF on stroke risk eliminated with multiple risk factors. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2013/08/130831110917.htm
European Society of Cardiology. "Impact of AF on stroke risk eliminated with multiple risk factors." ScienceDaily. www.sciencedaily.com/releases/2013/08/130831110917.htm (accessed August 29, 2014).

Share This




More Mind & Brain News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com
Alice in Wonderland Syndrome

Alice in Wonderland Syndrome

Ivanhoe (Aug. 27, 2014) It’s an unusual condition with a colorful name. Kids with “Alice in Wonderland” syndrome see sudden distortions in objects they’re looking at or their own bodies appear to change size, a lot like the main character in the Lewis Carroll story. Video provided by Ivanhoe
Powered by NewsLook.com
Stopping Schizophrenia Before Birth

Stopping Schizophrenia Before Birth

Ivanhoe (Aug. 27, 2014) Scientists have long called choline a “brain booster” essential for human development. Not only does it aid in memory and learning, researchers now believe choline could help prevent mental illness. Video provided by Ivanhoe
Powered by NewsLook.com
Personalized Brain Vaccine for Glioblastoma

Personalized Brain Vaccine for Glioblastoma

Ivanhoe (Aug. 27, 2014) Glioblastoma is the most common and aggressive brain cancer in humans. Now a new treatment using the patient’s own tumor could help slow down its progression and help patients live longer. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins