Featured Research

from universities, journals, and other organizations

Breakthrough model holds promise for treating Graves' disease

Date:
September 3, 2013
Source:
Endocrine Society
Summary:
Researchers have developed the first animal model simulating the eye complications associated with the thyroid condition Graves’ disease, a breakthrough that could pave the way for better treatments, according to a recent study.

Researchers have developed the first animal model simulating the eye complications associated with the thyroid condition Graves' disease, a breakthrough that could pave the way for better treatments, according to a recent study accepted for publication in The Endocrine Society's journal Endocrinology.

Related Articles


Graves' disease is an autoimmune disorder that causes the body to produce antibodies that attack the thyroid gland. The condition causes the thyroid gland to become overactive and produce too much thyroid hormone. If left untreated, it can lead to heart failure or osteoporosis.

Graves' disease is most common in women. About 1 percent of Caucasian women have autoimmune thyroid disease where the thyroid is either over- or underactive. Among those who have Graves' disease, more than half develop eye complications, according to the study's lead author, J. Paul Banga, PhD, of King's College London School of Medicine in the United Kingdom. These complications include Graves' orbitopathy, where swelling of tissue behind the eyes causes them to bulge outward. The condition can cause pain and lead to blindness.

"Current treatment options for eye complications associated with Graves' disease are limited," Banga said. "Better treatments are needed for Graves' orbitopathy to reduce the risks of permanent disfigurement and social stigma. Having an animal model to test preventative treatments could lead to important advances that will ultimately benefit people with Graves' disease."

The condition is currently treated with steroids, which can cause undesirable side effects such as weight gain and osteoporosis.

Although researchers have developed animal models of Graves' disease in the past, these models were challenging to replicate and none were able to simulate the eye problems seen in people with Graves' disease.

To develop the new model, researchers injected mice with small circular, double-stranded DNA molecules called plasmids. Over the course of three months, scientists used electronic pulses to ensure the DNA molecules were absorbed into the cells of each mouse. Mice that underwent this procedure developed eye problems like those seen in human patients who have Graves' disease, while the control group of mice did not develop these complications.

"The new animal model opens the door for scientists to conduct needed mechanistic studies and identify preventative therapies to minimize this painful and debilitating condition," Banga said.

Other researchers working on the study include: S. Moshkelgosha of King's College London School of Medicine; P-W. So and N. Deasy of King's College London; and S. Diaz-Cano of King's College Hospital NHS Trust in London.

The article, "Retrobulbar Inflammation, Adipogenesis and Acute Orbital Congestion in a Preclinical Female Mouse Model of Graves' Orbitopathy Induced by Thyrotropin Receptor Plasmid-in Vivo Electroporation," will be published in the September issue of Endocrinology.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "Breakthrough model holds promise for treating Graves' disease." ScienceDaily. ScienceDaily, 3 September 2013. <www.sciencedaily.com/releases/2013/09/130903101545.htm>.
Endocrine Society. (2013, September 3). Breakthrough model holds promise for treating Graves' disease. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2013/09/130903101545.htm
Endocrine Society. "Breakthrough model holds promise for treating Graves' disease." ScienceDaily. www.sciencedaily.com/releases/2013/09/130903101545.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins