Featured Research

from universities, journals, and other organizations

Disrupted heartbeat restored with regenerative intervention

Date:
September 3, 2013
Source:
Mayo Clinic
Summary:
Researchers have found a way to resynchronize cardiac motion following a heart attack using stem cells. Scientists implanted engineered stem cells, also known as induced pluripotent stem cells, into damaged regions of mouse hearts following a heart attack.

Mayo Clinic researchers have found a way to resynchronize cardiac motion following a heart attack using stem cells. Scientists implanted engineered stem cells, also known as induced pluripotent stem (iPS) cells, into damaged regions of mouse hearts following a heart attack. This regenerative approach successfully targeted the origin of abnormal cardiac motion, preventing heart failure.

The findings appear in the September issue of the Journal of Physiology.

"The discovery introduces -- for the first time -- stem cell-based 'biological resynchronization' as a novel means to treat cardiac dyssynchrony," says Andre Terzic, M.D., Ph.D., senior author of the study. Dr. Terzic is the Michael S. and Mary Sue Shannon Family Director, Center for Regenerative Medicine, and the Marriott Family Professor of Cardiovascular Diseases Research.

Muscle damage following a heart attack may disrupt normal heart conduction, resulting in a condition known as cardiac dyssynchrony. Current therapy uses pacing devices such as pacemakers; however, many patients with advanced heart failure do not respond favorably to these devices because heart tissue must be healthy for optimal outcome. Stem cell-based repair would offer a new solution to patients who would otherwise be resistant to device-based resynchronization.

"A high-resolution ultrasound revealed harmonized pumping where iPS cells were introduced to the previously damaged heart tissue," says Satsuki Yamada, M.D., Ph.D., first author of the study.

The study provides evidence that a stem cell-based intervention may be effective in synchronizing failing hearts. Additional studies will follow to validate the value of stem cell-based regenerative solutions in addressing abnormal cardiac motion in heart failure, ultimately leading to improved patient care.

"By harnessing the potential of regenerative medicine -- repairing the injured heart, in this case -- we will be increasingly able to provide more definitive solutions to our patients," adds Dr. Terzic.

Other members of the Mayo Clinic research team include Timothy Nelson, M.D., Ph.D.; Garvan Kane, M.D., Ph.D.; Almudena Martinez Fernandez, Ph.D.; Ruben Crespo-Diaz, Ph.D.; Yasuhiro Ikeda, D.V.M., Ph.D.; Carmen Perez-Terzic, M.D., Ph.D.; along with Jonathan Nesbitt; Lois Rowe; Diane Jech; and Courtney Rustad. The research was supported by the National Institutes of Health, American Heart Association, Marriott Heart Disease Research Program and the Mayo Clinic Center for Regenerative Medicine.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. Satsuki Yamada, Timothy J. Nelson, Garvan C. Kane, Almudena Martinez-Fernandez, Ruben J. Crespo-Diaz, Yasuhiro Ikeda, Carmen Perez-Terzic, Andre Terzic. iPS Cell Intervention Rescues Wall Motion Disparity Achieving Biological Cardiac Resynchronization Post-Infarction. The Journal of Physiology, 2013; DOI: 10.1113/jphysiol.2013.252288

Cite This Page:

Mayo Clinic. "Disrupted heartbeat restored with regenerative intervention." ScienceDaily. ScienceDaily, 3 September 2013. <www.sciencedaily.com/releases/2013/09/130903151851.htm>.
Mayo Clinic. (2013, September 3). Disrupted heartbeat restored with regenerative intervention. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2013/09/130903151851.htm
Mayo Clinic. "Disrupted heartbeat restored with regenerative intervention." ScienceDaily. www.sciencedaily.com/releases/2013/09/130903151851.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins