Featured Research

from universities, journals, and other organizations

Bisphosphonates could offer effective pain relief in osteoarthritis

Date:
September 5, 2013
Source:
University of St George's London
Summary:
Research has found that a drug normally given to osteoporosis sufferers could provide effective pain relief to patients with knee and hip osteoarthritis.

Bisphosphonates are a group of drugs known to change the structure of bone and are most often prescribed to patients with osteoporosis, a condition characterised by fragile bones.
Credit: St. George's University of London

St George's, University of London research has found that a drug normally given to osteoporosis sufferers could provide effective pain relief to patients with knee and hip osteoarthritis.

Bisphosphonates are a group of drugs known to change the structure of bone and are most often prescribed to patients with osteoporosis, a condition characterised by fragile bones.

It is unknown, however, whether these drugs could be used to reduce pain and discomfort for patients with the joint condition osteoarthritis, which causes cartilage damage, bony growths and sore tissue.

The researchers used existing studies to assess the effectiveness of a variety of bisphosphonates in patients suffering from osteoarthritis of the hand, knee, spine and hips.

Of 3832 patients studied, in most cases these drugs showed limited pain relief. However, a few studies did show benefit; the bisphosphonate alendronate was found to be more effective for patients with hip osteoarthritis than existing pain relieving drugs. Moreover, the use of zoledronate and alendronate, specific forms of bisphosphonates, improved pain in patients with knee and hip osteoarthritis at six months -- but longer term studies are needed.

Dr Nidhi Sofat, lead researcher, said:

"Osteoarthritis is the most common form of arthritis worldwide. It causes damage to bone and cartilage in the joints of affected people. Most treatment is focused around pain relief, as no robust treatments have been discovered that slow down the progression of the disease.

"Our study looked at whether there were any bisphosphonate drugs that have been shown to influence pain and/or disease progression that could be used in osteoarthritis treatment.

"We found that, generally, bisphosphonates are ineffective at managing pain associated with osteoarthritis. But zoledronate and alendronate, which are specific forms of bisphosphonates, do show the potential for effective pain management specifically in patients with knee and hip osteoarthritis.

"More research needs to be carried out to determine which patients could benefit most from this type of intervention. Osteoarthritis is a long term chronic condition, so it's essential that we work to understand whether the use of these medicines in the long term could be tolerated."

The research is published in full in the PLOS ONE journal


Story Source:

The above story is based on materials provided by University of St George's London. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alison J. Davis, Toby O. Smith, Caroline B. Hing, Nidhi Sofat. Are Bisphosphonates Effective in the Treatment of Osteoarthritis Pain? A Meta-Analysis and Systematic Review. PLoS ONE, 2013; 8 (9): e72714 DOI: 10.1371/journal.pone.0072714

Cite This Page:

University of St George's London. "Bisphosphonates could offer effective pain relief in osteoarthritis." ScienceDaily. ScienceDaily, 5 September 2013. <www.sciencedaily.com/releases/2013/09/130905112143.htm>.
University of St George's London. (2013, September 5). Bisphosphonates could offer effective pain relief in osteoarthritis. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2013/09/130905112143.htm
University of St George's London. "Bisphosphonates could offer effective pain relief in osteoarthritis." ScienceDaily. www.sciencedaily.com/releases/2013/09/130905112143.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins