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Study expands use of biomarker for early diagnosis of acute kidney injury

Date:
September 5, 2013
Source:
Cincinnati Children's Hospital Medical Center
Summary:
A biomarker test developed initially to identify early acute kidney injury after surgery has been shown to successfully detect it in emergency room patients with a variety of urgent health issues. The findings expand the overall utility and potential medical settings for using the test, according to researchers.

A biomarker test developed initially to identify early acute kidney injury (AKI) after surgery has been shown to successfully detect AKI in emergency room patients with a variety of urgent health issues.

In a study published online Sept. 5 in the Clinical Journal of the American Society of Nephrology, the findings expand the overall utility and potential medical settings for using the test, according to researchers.

The test measures the protein neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker of early AKI. It was invented by researchers at Cincinnati Children's Hospital Medical Center to detect AKI earlier than existing methods, and to more promptly begin treatment.

"The majority of our studies on NGAL have been performed in well controlled settings of hospital-acquired AKI, such as cardiac surgery, contrast administration or other critically ill patients," said Prasad Devarajan, MD, senior author and director of Nephrology and Hypertension at Cincinnati Children's. "The purpose of this study was to determine the biomarker's accuracy in a diverse group of patients admitted from the emergency department, where patients with early signs of AKI are often misdiagnosed."

The study involved patients admitted through the emergency room of Fernando Fonseca Hospital in Portugal, which also closely collaborated on the study. The findings demonstrate the NGAL test, which uses a single drop of blood and provides results within 15 minutes, was able to accurately distinguish AKI from reversible transient kidney dysfunction.

Of 616 patients who participated in the study, individuals who were subsequently diagnosed with true AKI had the highest levels of NGAL detected at the time of hospital admission. The study also identified a cutoff point in NGAL levels above which the risk of acute kidney injury increases tenfold.

Results of a study previously published in 2008 by Devarajan showed that the NGAL test predicted AKI in pediatric heart surgery patients within hours instead of days, allowing treatment that prevented serious damage to kidneys. Prior to the NGAL test, serum creatinine was the only reliable method for detecting kidney damage; however, the long wait for results often resulted in permanent kidney damage.

With a growing number of patients coming to emergency rooms with community-acquired AKI, Devarajan says having a rapid, reliable method of detecting kidney injury is increasingly important.

"This latest study showed that this simple laboratory test provides an accurate prediction of acute kidney injury and its severity in a diverse clinical setting," said Devarajan. "The identification of biomarkers that differentiate intrinsic AKI from transient reversible forms of renal dysfunction and predict outcomes is a high priority."

Funding for the study came from the National Institutes of Health (DK069749, P50 DK096418), the Portuguese Nephrology Society, Fernando Fonseca Hospital EPE and Fundaηγo Nacional para a Ciκncia e Tecnologia in Portugal.

Devarajan is a co-inventor on patents submitted on using NGAL as a biomarker of kidney injury. A license for commercial development of the technology has been granted to Alere, Inc., which did not play any role in the design, execution, analysis or reporting of the study. The test is currently approved for use outside of the United States and is currently under regulatory review by the U.S. Food and Drug Administration for possible domestic use.


Story Source:

The above story is based on materials provided by Cincinnati Children's Hospital Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Karina Soto, Ana Luisa Papoila, Silvia Coelho, Michael Bennett, Qing Ma, Bruno Rodrigues, Pedro Fidalgo, Francisca Frade, and Prasad Devarajan. Plasma NGAL for the Diagnosis of AKI in Patients Admitted from the Emergency Department Setting. Clinical Journal of the American Society of Nephrology, September 2013

Cite This Page:

Cincinnati Children's Hospital Medical Center. "Study expands use of biomarker for early diagnosis of acute kidney injury." ScienceDaily. ScienceDaily, 5 September 2013. <www.sciencedaily.com/releases/2013/09/130905203014.htm>.
Cincinnati Children's Hospital Medical Center. (2013, September 5). Study expands use of biomarker for early diagnosis of acute kidney injury. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2013/09/130905203014.htm
Cincinnati Children's Hospital Medical Center. "Study expands use of biomarker for early diagnosis of acute kidney injury." ScienceDaily. www.sciencedaily.com/releases/2013/09/130905203014.htm (accessed August 27, 2014).

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