Featured Research

from universities, journals, and other organizations

Rapid diagnostic tests decrease waiting time for TB patients

Date:
September 8, 2013
Source:
European Lung Foundation
Summary:
Results of a new study suggest that three new diagnostic tests could each be used to successfully diagnose drug resistance in tuberculosis (TB) patients in a quarter of the time taken by the current method.

Results of a new study suggest that three new diagnostic tests could each be used to successfully diagnose drug resistance in tuberculosis (TB) patients in a quarter of the time taken by the current method.

Related Articles


The research, presented today at the European Respiratory Society's Annual Congress in Barcelona, has provided evidence that each test could be used as an effective alternative to standard testing, increasing the possibilities open to clinicians.

Drug susceptibility tests are carried out in people with active TB in order to identify which drugs the TB bacteria are sensitive or resistant to.

It is essential that these are identified as early as possible so that the patient can be provided with the most effective treatment and therefore the most rapid cure, and to prevent the development of even more drug-resistant TB. This is particularly important for patients with extremely-drug-resistant TB (XDR-TB), who may have a short life expectancy if not treated properly.

Traditional methods of drug-susceptibility testing can take anywhere between 21 days to 3 months because a sputum sample must first be collected and cultured.

A new study carried out by researchers in the USA analysed three new tests: pyrosequencing, a DNA sequencing technique; the HAIN line probe test, a commercial test that detects genetic mutations in the bacteria; and the microscopic observation drug susceptibility (MODS), test which screens samples under the microscope.

The researchers investigated the effectiveness of the new tests in over 1,000 patients in India, Moldova and South Africa. They performed the standard drug susceptibility tests, alongside the three new tests and evaluated drug resistance to five drugs: isoniazid, rifampin, moxifloxacin, ofloxacin, amikacin, Capreomycin, and kanamycin.

The results showed that the MODS test took 15 days to complete, the pyrosequencing took 8 days to complete and the line probe assay took 5 days. All three tests produced the same results as the standard testing - 95-98% of the time for almost all the drugs.

Professor Antonino Catanzaro, from the University California, San Diego, said: "Our findings suggest these three tests could provide a quicker way to identify patients who need alternative treatment regimens. This is very important and could potentially save lives as well as help to curb the rise of drug resistant TB. There are benefits and disadvantages to each test. For example, the MODS test, although the slowest of the three new tests we looked at, is much cheaper. It is important to have this range of options available so that TB treatment programmes across the world can assess which method is right for them including consideration of the financial restrictions they work within."


Story Source:

The above story is based on materials provided by European Lung Foundation. Note: Materials may be edited for content and length.


Cite This Page:

European Lung Foundation. "Rapid diagnostic tests decrease waiting time for TB patients." ScienceDaily. ScienceDaily, 8 September 2013. <www.sciencedaily.com/releases/2013/09/130908135614.htm>.
European Lung Foundation. (2013, September 8). Rapid diagnostic tests decrease waiting time for TB patients. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2013/09/130908135614.htm
European Lung Foundation. "Rapid diagnostic tests decrease waiting time for TB patients." ScienceDaily. www.sciencedaily.com/releases/2013/09/130908135614.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins