Featured Research

from universities, journals, and other organizations

Rapid diagnostic tests decrease waiting time for TB patients

Date:
September 8, 2013
Source:
European Lung Foundation
Summary:
Results of a new study suggest that three new diagnostic tests could each be used to successfully diagnose drug resistance in tuberculosis (TB) patients in a quarter of the time taken by the current method.

Results of a new study suggest that three new diagnostic tests could each be used to successfully diagnose drug resistance in tuberculosis (TB) patients in a quarter of the time taken by the current method.

The research, presented today at the European Respiratory Society's Annual Congress in Barcelona, has provided evidence that each test could be used as an effective alternative to standard testing, increasing the possibilities open to clinicians.

Drug susceptibility tests are carried out in people with active TB in order to identify which drugs the TB bacteria are sensitive or resistant to.

It is essential that these are identified as early as possible so that the patient can be provided with the most effective treatment and therefore the most rapid cure, and to prevent the development of even more drug-resistant TB. This is particularly important for patients with extremely-drug-resistant TB (XDR-TB), who may have a short life expectancy if not treated properly.

Traditional methods of drug-susceptibility testing can take anywhere between 21 days to 3 months because a sputum sample must first be collected and cultured.

A new study carried out by researchers in the USA analysed three new tests: pyrosequencing, a DNA sequencing technique; the HAIN line probe test, a commercial test that detects genetic mutations in the bacteria; and the microscopic observation drug susceptibility (MODS), test which screens samples under the microscope.

The researchers investigated the effectiveness of the new tests in over 1,000 patients in India, Moldova and South Africa. They performed the standard drug susceptibility tests, alongside the three new tests and evaluated drug resistance to five drugs: isoniazid, rifampin, moxifloxacin, ofloxacin, amikacin, Capreomycin, and kanamycin.

The results showed that the MODS test took 15 days to complete, the pyrosequencing took 8 days to complete and the line probe assay took 5 days. All three tests produced the same results as the standard testing - 95-98% of the time for almost all the drugs.

Professor Antonino Catanzaro, from the University California, San Diego, said: "Our findings suggest these three tests could provide a quicker way to identify patients who need alternative treatment regimens. This is very important and could potentially save lives as well as help to curb the rise of drug resistant TB. There are benefits and disadvantages to each test. For example, the MODS test, although the slowest of the three new tests we looked at, is much cheaper. It is important to have this range of options available so that TB treatment programmes across the world can assess which method is right for them including consideration of the financial restrictions they work within."


Story Source:

The above story is based on materials provided by European Lung Foundation. Note: Materials may be edited for content and length.


Cite This Page:

European Lung Foundation. "Rapid diagnostic tests decrease waiting time for TB patients." ScienceDaily. ScienceDaily, 8 September 2013. <www.sciencedaily.com/releases/2013/09/130908135614.htm>.
European Lung Foundation. (2013, September 8). Rapid diagnostic tests decrease waiting time for TB patients. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2013/09/130908135614.htm
European Lung Foundation. "Rapid diagnostic tests decrease waiting time for TB patients." ScienceDaily. www.sciencedaily.com/releases/2013/09/130908135614.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins