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Alternative approaches to surgical valve replacement offer comparable outcomes

Date:
October 1, 2013
Source:
Society of Thoracic Surgeons
Summary:
Patients with aortic stenosis who are ineligible for surgical valve replacement as well as the traditional approach to transcatheter aortic valve replacement (TAVR) may have comparable outcomes when the surgeon uses an alternative access TAVR approach.

Patients with aortic stenosis who are ineligible for surgical valve replacement as well as the traditional approach to transcatheter aortic valve replacement (TAVR) may have comparable outcomes when the surgeon uses an alternative access TAVR approach, according to a study in the October 2013 issue of The Annals of Thoracic Surgery.

"Our experience demonstrated that cardiac surgeons and cardiologists must utilize a multitude of access options in TAVR to achieve minimal morbidity and mortality with excellent outcomes," said Vinod H. Thourani, MD, from Emory University in Atlanta and lead author of the study.

TAVR using the transfemoral (TF) approach (via the groin) was recently approved in the United States for inoperable or high-risk patients with aortic stenosis, the most common acquired valvular disease in adults. Aortic stenosis is characterized by a narrowing of the opening to the aortic valve. Surgical aortic valve replacement is the treatment of choice; however, 25% of patients may be ineligible for surgery for reasons such as frailty or additional disease.

TF TAVR was approved for these high-risk or inoperable patients, but some patients have too much disease in the femoral artery to permit using this approach.

To understand more about the outcomes from other TAVR approaches, Dr. Thourani and his colleagues at Emory conducted a single-center retrospective review of 44 inoperable patients who underwent alternative access TAVR from November 2011 to April 2012. Alternative access approaches included transapical (TA -- via the heart muscle), transaortic (TAo -- via the aorta), and transcarotid (TCa -- via the right common carotid artery) TAVR.

Of the 44 patients reviewed, 18 -- less than half -- were eligible for TF, while 11 underwent TA, 12 underwent TAo, and three underwent TCa procedures.

Thirty days after the TAVR procedures, the researchers found no difference among the groups in mortality and no incidents of myocardial infarction or stroke. Study participants implanted using a non-TF approach, however, experienced longer average lengths of hospital stays.

"What we have learned from this study," said Dr. Thourani, "is that the TAVR physician, be it a cardiologist or cardiac surgeon, should feel comfortable utilizing a variety of TAVR techniques. This will allow the most appropriate tailoring of the TAVR procedure for optimal patient outcomes."

The U.S. Food and Drug Administration recently announced its approval of alternative access approaches for TAVR using the Edwards Sapien Transcatheter Heart Valve, making the procedure available to an expanded group of patients who have inoperable aortic valve stenosis. The new device labeling removes references to specific access points now making it available for inoperable patients who require one of these alternative access points.


Story Source:

The above story is based on materials provided by Society of Thoracic Surgeons. Note: Materials may be edited for content and length.


Journal Reference:

  1. Vinod H. Thourani, Rebecca L. Gunter, Soumya Neravetla, Peter Block, Robert A. Guyton, Patrick Kilgo, Stamatios Lerakis, Chandan Devireddy, Bradley Leshnower, Kreton Mavromatis, James Stewart, Amy Simone, Patricia Keegan, Tom C. Nguyen, John Merlino, Vasilis Babaliaros. Use of Transaortic, Transapical, and Transcarotid Transcatheter Aortic Valve Replacement in Inoperable Patients. The Annals of Thoracic Surgery, 2013; 96 (4): 1349 DOI: 10.1016/j.athoracsur.2013.05.068

Cite This Page:

Society of Thoracic Surgeons. "Alternative approaches to surgical valve replacement offer comparable outcomes." ScienceDaily. ScienceDaily, 1 October 2013. <www.sciencedaily.com/releases/2013/10/131001090004.htm>.
Society of Thoracic Surgeons. (2013, October 1). Alternative approaches to surgical valve replacement offer comparable outcomes. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2013/10/131001090004.htm
Society of Thoracic Surgeons. "Alternative approaches to surgical valve replacement offer comparable outcomes." ScienceDaily. www.sciencedaily.com/releases/2013/10/131001090004.htm (accessed August 1, 2014).

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