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Statins do not improve survival for adults with ventilator-associated pneumonia

Date:
October 9, 2013
Source:
American Medical Association (AMA)
Summary:
Researchers conducted a study to determine whether statin therapy decreased day-28 mortality among intensive care unit patients with ventilator-associated pneumonia. The results suggest they do not.

Laurent Papazian, M.D., Ph.D., of Hτpital Nord, Marseille, France, and colleagues conducted a study to determine whether statin therapy decreased day-28 mortality among intensive care unit patients with ventilator-associated pneumonia.

Observational studies have reported that statins improve outcomes of various infections. Ventilator-associated pneumonia (VAP) is the most common infection in the intensive care unit (ICU) and is diagnosed in approximately 8 to 28 percent of ICU patients receiving mechanical ventilation. Ventilator-associated pneumonia is associated with increased mortality rates and high health care costs. New treatments are needed to improve the outcomes of VAP, according to background information in the article appearing in JAMA.

The trial, performed in 26 intensive care units in France from January 2010 to March 2013, randomized 300 patients to receive simvastatin (60 mg) or placebo, started on the same day as antibiotic therapy and given until ICU discharge, death, or day 28, whichever occurred first.

The study was stopped for futility at the first scheduled interim analysis after enrollment of the 300 patients. The researchers found that day-28 mortality was not lower in the simvastatin group (21.2 percent) than in the placebo group (15.2 percent). There were no differences in day-14, ICU, or hospital mortality rates, or in duration of mechanical ventilation.

“These findings do not support the use of statins [for] improving VAP outcomes,” the authors conclude.


Story Source:

The above story is based on materials provided by American Medical Association (AMA). Note: Materials may be edited for content and length.


Journal Reference:

  1. Laurent Papazian. Effect of Statin Therapy on Mortality in Patients With Ventilator-Associated Pneumonia. JAMA, 2013; DOI: 10.1001/jama.2013.280031

Cite This Page:

American Medical Association (AMA). "Statins do not improve survival for adults with ventilator-associated pneumonia." ScienceDaily. ScienceDaily, 9 October 2013. <www.sciencedaily.com/releases/2013/10/131009095717.htm>.
American Medical Association (AMA). (2013, October 9). Statins do not improve survival for adults with ventilator-associated pneumonia. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2013/10/131009095717.htm
American Medical Association (AMA). "Statins do not improve survival for adults with ventilator-associated pneumonia." ScienceDaily. www.sciencedaily.com/releases/2013/10/131009095717.htm (accessed April 17, 2014).

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