Featured Research

from universities, journals, and other organizations

Risk of death of fluid replacement therapies compared for critically ill patients

Date:
October 9, 2013
Source:
American Medical Association (AMA)
Summary:
Researchers have conducted a study to compare the effects of 2 types of intravenous fluids on survival for critically ill patients in an intensive care unit.

Djillali Annane, M.D., Ph.D., of Raymond Poincare Hospital, Garches, France, and colleagues conducted a study to compare the effects of 2 types of intravenous fluids on survival for critically ill patients in an intensive care unit.

Thousands of patients in intensive care units (ICUs) throughout the world are treated every day with intravenous fluids, mainly to restore effective blood volume and perfusion of organs. Fluid therapy includes a broad variety of products that are categorized as crystalloids and colloids: crystalloids are salts; colloids are salts and gelatin, starch or protein. Compared with crystalloids, colloid solutions expand blood volume and last longer. However, colloids may increase illness and death in critically ill patients and many physicians considered crystalloids the best fluid therapy in this population, according to background information in the article appearing in JAMA.

The trial included 2,857 ICU patients who required fluid resuscitation for sepsis or trauma, or hypovolemic (decreased blood volume) shock for patients without sepsis or trauma at 57 intensive care units in France, Belgium, North Africa, and Canada. Recruitment into the trial started in February 2003 and ended in August 2012 with follow-up until November 2012. Patients were randomly assigned to crystalloids (n = 1,443) or colloids (n = 1,414) for all fluid intervention (except fluid maintenance) throughout their ICU stay. The primary outcome was death within 28 days.

The study reports no difference in outcomes between groups; there were 359 deaths (25.4 percent) among patients treated with colloids vs. 390 deaths (27.0 percent) among patients treated with crystalloids. At 90 days, there were 434 deaths (30.7 percent) among patients treated with colloids vs. 493 deaths (34.2 percent) among patients treated with crystalloids.

"In conclusion, among ICU patients with hypovolemia, the use of colloids compared with crystalloids did not result in a significant difference in 28-day mortality. Although 90-day mortality was lower among patients receiving colloids, this finding should be considered exploratory and requires further study before reaching conclusions about efficacy," the authors write.


Story Source:

The above story is based on materials provided by American Medical Association (AMA). Note: Materials may be edited for content and length.


Journal Reference:

  1. Djillali Annane. Effects of Fluid Resuscitation With Colloids vs Crystalloids on Mortality in Critically Ill Patients Presenting With Hypovolemic Shock. JAMA, 2013; DOI: 10.1001/jama.2013.280502

Cite This Page:

American Medical Association (AMA). "Risk of death of fluid replacement therapies compared for critically ill patients." ScienceDaily. ScienceDaily, 9 October 2013. <www.sciencedaily.com/releases/2013/10/131009095719.htm>.
American Medical Association (AMA). (2013, October 9). Risk of death of fluid replacement therapies compared for critically ill patients. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2013/10/131009095719.htm
American Medical Association (AMA). "Risk of death of fluid replacement therapies compared for critically ill patients." ScienceDaily. www.sciencedaily.com/releases/2013/10/131009095719.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com
House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Uganda on Alert for Ebola but No Confirmed Cases

Uganda on Alert for Ebola but No Confirmed Cases

AFP (July 31, 2014) Uganda's health minister said on Thursday that there are no confirmed cases of Ebola in the country, but that it remained on alert for cases of the deadly virus. Uganda has suffered Ebola outbreaks in the past, most recently in 2012. Duration: 00:59 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins