Featured Research

from universities, journals, and other organizations

Innovative concept for knee cartilage treatment

Date:
October 9, 2013
Source:
Schweizerischer Nationalfonds zur Foerderung der wissenschaftlichen Forschung
Summary:
Researchers have developed a material that can be used for the controlled release of a substance when subjected to cyclic mechanical loading. This work, carried out within the context of the National Research Programme “Smart Materials," offers a potential treatment method for specific tissues such as knee cartilage.

Researchers have developed a material that can be used for the controlled release of a substance when subjected to cyclic mechanical loading. This work, carried out within the context of the National Research Programme "Smart Materials" (NRP 62), offers a potential treatment method for specific tissues such as knee cartilage.

In order to regenerate, knee cartilage, paradoxically, needs to be placed under mechanical stress, as happens whenever we take a step and our knees take our weight. When stimulated in this way, the cartilage cells develop receptors that are sensitive to the growth factors produced by the organism. It is also at this very moment that they would be most receptive to medication. Working on this basis, Dominique Pioletti and Harm-Anton Klok from EPF Lausanne have developed a smart material that only releases a substance when the material is mechanically loaded.

Threshold effect

As they describe in a recent publication, their material takes the form of a hydrogel matrix, liposome-type nanoparticles and, finally, a payload -- in this case a dye. When subjected to cyclic mechanical loading, the hydrogel matrix heats up. Once subjected to heat, the diameter of the liposomes shrinks significantly. This frees up space in the matrix, increasing its permeability and facilitating the release of the dye from the matrix. "One of the main difficulties has been the development of nanoparticles that respond to our specification," explains Dominique Pioletti. "Basically, for the concept to work, their response to the heating process must have a very clear threshold between the two to three degrees that separate the static and stimulated states."

The researchers then wanted to verify that it was actually the heating process resulting from the repetition of the mechanical loading that caused the dye to be released. During an initial experiment, the material was subjected to cyclic mechanical loading but the heat produced was evacuated in order to prevent any local temperature increase in the material. "This test enabled us to exclude a sponge-type function, whereby the dye was only being released as a result of the pressure," explains Dominique Pioletti. During a second experiment, the nanoparticles were removed. The matrix heated up as expected due to the cyclic mechanical loading but none of the dye was released. The researchers concluded that the three elements of the composite material were required for the system as a whole to function as intended.

Long-term prospects Whilst the researchers have been able to demonstrate the validity of their concept, Dominique Pioletti stresses that a future treatment is still a long way off. "First of all we need to develop a hydrogel and nanoparticles that are safe and biodegradable, before progressing to clinical trials. And, above all, we need to find partners interested in investing in our project."


Story Source:

The above story is based on materials provided by Schweizerischer Nationalfonds zur Foerderung der wissenschaftlichen Forschung. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mohamadreza Nassajian Moghadam, Vitaliy Kolesov, Arne Vogel, Harm-Anton Klok, Dominique P. Pioletti. Controlled release from a mechanically-stimulated thermosensitive self-heating composite hydrogel. Biomaterials, 2013; DOI: 10.1016/j.biomaterials.2013.09.065

Cite This Page:

Schweizerischer Nationalfonds zur Foerderung der wissenschaftlichen Forschung. "Innovative concept for knee cartilage treatment." ScienceDaily. ScienceDaily, 9 October 2013. <www.sciencedaily.com/releases/2013/10/131009095954.htm>.
Schweizerischer Nationalfonds zur Foerderung der wissenschaftlichen Forschung. (2013, October 9). Innovative concept for knee cartilage treatment. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2013/10/131009095954.htm
Schweizerischer Nationalfonds zur Foerderung der wissenschaftlichen Forschung. "Innovative concept for knee cartilage treatment." ScienceDaily. www.sciencedaily.com/releases/2013/10/131009095954.htm (accessed April 18, 2014).

Share This



More Matter & Energy News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Small Reactors Could Be Future of Nuclear Energy

Small Reactors Could Be Future of Nuclear Energy

AP (Apr. 17, 2014) After the Fukushima nuclear disaster, the industry fell under intense scrutiny. Now, small underground nuclear power plants are being considered as the possible future of the nuclear energy. (April 17) Video provided by AP
Powered by NewsLook.com
Honda's New ASIMO Robot, More Human-Like Than Ever

Honda's New ASIMO Robot, More Human-Like Than Ever

AFP (Apr. 17, 2014) It walks and runs, even up and down stairs. It can open a bottle and serve a drink, and politely tries to shake hands with a stranger. Meet the latest ASIMO, Honda's humanoid robot. Duration: 00:54 Video provided by AFP
Powered by NewsLook.com
German Researchers Crack Samsung's Fingerprint Scanner

German Researchers Crack Samsung's Fingerprint Scanner

Newsy (Apr. 16, 2014) German researchers have used a fake fingerprint made from glue to bypass the fingerprint security system on Samsung's new Galaxy S5 smartphone. Video provided by Newsy
Powered by NewsLook.com
Porsche CEO Says Supercar Is Not Dead: Cue the Spyder 918

Porsche CEO Says Supercar Is Not Dead: Cue the Spyder 918

TheStreet (Apr. 16, 2014) The Porsche Spyder 918 proves that, in an automotive world obsessed with fuel efficiency, the supercar is not dead. Porsche North America CEO Detlev von Platen attributes the brand's consistent sales growth -- 21% in 2013 -- with an investment in new technology and expanded performance dynamics. The hybrid Spyder 918 has 887 horsepower and 944 lb-ft of torque, but it can run 18 miles on just an electric charge. The $845,000 vehicle is not a consumer-targeted vehicle but a brand statement. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins