Featured Research

from universities, journals, and other organizations

ADHD drug effective for people with dependency

Date:
October 14, 2013
Source:
Karolinska Institutet
Summary:
People with ADHD and dependency rarely respond as they should to ADHD drugs. A randomised study now shows that it is possible to obtain the desired efficacy by administering the drug in higher doses.

People with ADHD and dependency rarely respond as they should to ADHD drugs. A randomised study from Karolinska Institutet in Sweden now shows that it is possible to obtain the desired efficacy by administering the drug in higher doses. The results of the study are published in the scientific journal Addiction.

ADHD is much more common in people who use drugs than in the population at large. ADHD can be treated with methylphenidate, a CNS stimulant used for both children and adults. However, no previous studies have been able to show that methylphenidate is effective against ADHD in people with dependency. One possible reason for this lack of potency is that the doses tested were too low to have an effect on people with ADHD and long-standing dependency, since such people have often developed a tolerance to CNS stimulants.

In this latest study, researchers examined the effect of the drug on prison inmates with ADHD and an amphetamine dependency, using doses up to double those administered in previous studies on people with dependency. What they found was that the experimental group had fewer relapses into drug use, displayed fewer ADHD symptoms and adhered to their treatment regimens for longer than the placebo group.

"We've shown for the first time that ADHD in these people is treatable," says lead-author Dr Maija Konstenius at the Department of Clinical Neuroscience. "Moreover, the treatment led to fewer relapses in drug use, which is a very significant finding since a return to crime is often linked to drug abuse in this group."

The present study was a randomised placebo-controlled study involving 54 incarcerated men diagnosed with ADHD and with amphetamine dependencies. The participants were randomly assigned to either of two groups, one that received methylphenidate (Concerta) and one that received a placebo (sugar pill) for a total of 24 weeks. The participants began their treatment two weeks before their release and then continued it during non-custodial care. They also received psychological therapy to help them handle the risk of relapsing into drug use.

The study was conducted in partnership with the Stockholm County Council and the Swedish Prison and Probation Service and was financed by grants from the Swedish Research Council and other bodies.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maija Konstenius, Nitya Jayaram-Lindstrφm, Joar Guterstam, Olof Beck, Bjφrn Philips, Johan Franck. Methylphenidate for ADHD and Drug Relapse in Criminal Offenders with Substance Dependence: A 24-week Randomized Placebo-controlled Trial. Addiction, 2013; DOI: 10.1111/add.12369

Cite This Page:

Karolinska Institutet. "ADHD drug effective for people with dependency." ScienceDaily. ScienceDaily, 14 October 2013. <www.sciencedaily.com/releases/2013/10/131014093913.htm>.
Karolinska Institutet. (2013, October 14). ADHD drug effective for people with dependency. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/10/131014093913.htm
Karolinska Institutet. "ADHD drug effective for people with dependency." ScienceDaily. www.sciencedaily.com/releases/2013/10/131014093913.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins