Featured Research

from universities, journals, and other organizations

New take on efficient delivery in regenerative medicine

Date:
October 22, 2013
Source:
Stockholm University
Summary:
An international research group has successfully tested the use of a new type of porous material for the efficient delivery of key molecules to transplanted cells derived from stem cells. These results can lead to improvements in the way stem cell-based neurodegenerative diseases are treated.

An international research group has successfully tested the use of a new type of porous material for the efficient delivery of key molecules to transplanted cells derived from stem cells. These results can lead to improvements in the way stem cell-based neurodegenerative diseases are treated.

Related Articles


A group of researchers based in Sweden, Denmark and Japan has successfully tested in animal models the use of a new type of porous material for the efficient delivery of key molecules to transplanted cells derived from stem cells. The researchers have developed a novel technological approach for the local delivery of exogenous trophic factor mimetics to transplanted cells using specifically designed silica nanoporous particles. This is potentially a versatile and widely applicable strategy for the efficient differentiation and functional integration of stem cell derivatives upon transplantation, and it can serve as a foundation for improving stem cell-based neuroregenerative protocols, for example Parkinson's disease.

"We are working to provide standard and reproducible methods for the differentiation and implementation of Stem Cell therapies using this type of approach, which couples material science with regenerative medicine," said Dr. Alfonso Garcia-Bennett, one of the leading authors of the study currently working at the Department of Materials and Environmental Chemistry, Stockholm University.

"We demonstrated that delivering key molecules for the differentiation of stem cells in vivo with these particles enabled not only robust functional differentiation of motor neurons from transplanted embryonic stem cells but also improves their long-term survival," said Elena Kozlova, co-director of the study and Associated Professor at the Department of Neuroscience, Uppsala University.

The researchers are already working together with two companies in order to speed up the process of commercialising their innovative approach in the form of a standard differentiation kit that will allow other scientists and clinicians to reproduce their work in their own laboratories.


Story Source:

The above story is based on materials provided by Stockholm University. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. E. Garcia-Bennett, M. Kozhevnikova, N. Konig, C. Zhou, R. Leao, T. Knopfel, S. Pankratova, C. Trolle, V. Berezin, E. Bock, H. Aldskogius, E. N. Kozlova. Delivery of Differentiation Factors by Mesoporous Silica Particles Assists Advanced Differentiation of Transplanted Murine Embryonic Stem Cells. Stem Cells Translational Medicine, 2013; DOI: 10.5966/sctm.2013-0072

Cite This Page:

Stockholm University. "New take on efficient delivery in regenerative medicine." ScienceDaily. ScienceDaily, 22 October 2013. <www.sciencedaily.com/releases/2013/10/131022091630.htm>.
Stockholm University. (2013, October 22). New take on efficient delivery in regenerative medicine. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2013/10/131022091630.htm
Stockholm University. "New take on efficient delivery in regenerative medicine." ScienceDaily. www.sciencedaily.com/releases/2013/10/131022091630.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins