Featured Research

from universities, journals, and other organizations

Biomarkers could lead to early diagnosis of colorectal cancer

Date:
October 30, 2013
Source:
McGill University Health Centre
Summary:
Diagnosing colorectal cancer is complex; it relies on significant invasive tests and subjective evaluations. This process may soon become much easier thanks to a medical breakthrough. Researchers have identified genetic changes in the colon lining, or mucosa, in colorectal cancer patients that could be used as biomarkers of the disease. That will allow doctors to diagnose patients earlier, more accurately and less invasively.

Diagnosing colorectal cancer (CRC) is complex; it relies on significant invasive tests and subjective evaluations. This process may soon become much easier thanks to a medical breakthrough by scientists at the Research Institute of the McGill University Health Centre (RI-MUHC). The researchers have identified genetic changes in the colon lining, or mucosa, in colorectal cancer patients that could be used as biomarkers of the disease. That will allow doctors to diagnose patients earlier, more accurately and less invasively. The study, recently published online, in Cancer Prevention Research, has implications for the nearly one million people diagnosed annually worldwide.

Related Articles


"The gold standard of diagnosis is currently colonoscopy," says corresponding author of the study, Dr. Rima Rozen, a geneticist from the Departments of Human Genetics and Pediatrics at The Montreal Children's Hospital of the MUHC and McGill University. "This is an invasive procedure, where the physician looks for abnormal tissue or growths also known as polyps." Additionally, given surging demand for colonoscopies, this research may ultimately offer an alternative option for early diagnosis, paving the way for the reduction in wait time.

According to Dr. Rozen, who is also a researcher of the Medical Genetics and Genomics Axis at the RI-MUHC, having genetic biomarkers of CRC will enhance the diagnostic procedure. "This new method could help to avoid false negative findings, which can occur in 10 to 15 per cent of endoscopic procedures," she says. "The key is using the right genes. I believe the ones we have identified are good candidates."

Dr. Rozen and her colleagues first identified five possible abnormal marker genes in a colon cancer mouse model. They then confirmed that these candidate biomarker genes were also abnormal in tissue obtained from colon cancer patients. "Not only did this show that our mouse model mimics the human disease," says Dr. Rozen. "But more importantly, it identified genes that could be used for colorectal cancer diagnosis."

Interestingly, the abnormal patterns of these genes were detected in otherwise normal colon cells that were not near the tumor site. "CRC develops in different stages," says Dr. Rozen. "This finding suggests that it may be possible to take tissue samples in more accessible regions of the gastrointestinal tract or, ideally, in blood or stool, and look for biomarkers as an early indicator of disease."


Story Source:

The above story is based on materials provided by McGill University Health Centre. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Leclerc, N. Levesque, Y. Cao, L. Deng, Q. Wu, J. Powell, C. Sapienza, R. Rozen. Genes with Aberrant Expression in Murine Preneoplastic Intestine Show Epigenetic and Expression Changes in Normal Mucosa of Colon Cancer Patients. Cancer Prevention Research, 2013; 6 (11): 1171 DOI: 10.1158/1940-6207.CAPR-13-0198

Cite This Page:

McGill University Health Centre. "Biomarkers could lead to early diagnosis of colorectal cancer." ScienceDaily. ScienceDaily, 30 October 2013. <www.sciencedaily.com/releases/2013/10/131030093150.htm>.
McGill University Health Centre. (2013, October 30). Biomarkers could lead to early diagnosis of colorectal cancer. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2013/10/131030093150.htm
McGill University Health Centre. "Biomarkers could lead to early diagnosis of colorectal cancer." ScienceDaily. www.sciencedaily.com/releases/2013/10/131030093150.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins