Featured Research

from universities, journals, and other organizations

A mimic of 'good cholesterol' could treat cardiovascular, other diseases

Date:
October 30, 2013
Source:
American Chemical Society
Summary:
A new type of "good cholesterol," made in the lab, could one day deliver drugs to where they are needed in the body to treat disease or be used in medical imaging, according to scientists. The report states that the high-density lipoprotein mimic is easy to make in large amounts.

A new type of "good cholesterol," made in the lab, could one day deliver drugs to where they are needed in the body to treat disease or be used in medical imaging, according to scientists. Their report on the high-density lipoprotein (HDL) mimic, which is easy to make in large amounts, appears in the journal ACS Nano.

Related Articles


Zahi A. Fayad, Robert Langer, YongTae (Tony) Kim, Francois Fay, Willem Mulder and colleagues explain that HDL is a natural nanoparticle that carries cholesterol throughout the body. Because it acts like a scavenger, collecting cholesterol and taking it to the liver for breakdown, HDL has emerged from being simply a marker for cardiovascular disease -- the number one killer of men and women in America -- to being a therapeutic agent. Clinical trials are testing its potential to combat atherosclerosis, the build-up of plaques in blood vessels that can lead to heart attacks or strokes. Scientists are also exploring new ways to use it for drug delivery. But HDL is complex and comes in many varieties. It takes several labor-intensive steps to get a uniform collection of these particles with current methods, which aren't easily scaled up for clinical applications. That's why Fayad and Langer's groups devised a new and improved method for making HDL-like particles.

The scientists showed that microfluidics -- the same technology that enabled the invention of inkjet printers -- allowed them to make material called µHDL that looks and acts like HDL in a single, rapid step. Not only does this material offer a possible, easy new way to treat cardiovascular disease, but the researchers also attached drug compounds, as well as dyes and nanocrystals used in medical imaging (such as those used for MRIs and CT scans), to the particles.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. YongTae Kim, Francois Fay, David P. Cormode, Brenda L. Sanchez-Gaytan, Jun Tang, Elizabeth J. Hennessy, Mingming Ma, Kathryn Moore, Omid C. Farokhzad, Edward Allen Fisher, Willem J. M. Mulder, Robert Langer, Zahi A. Fayad. Single Step Reconstitution of Multifunctional High-Density Lipoprotein-Derived Nanomaterials Using Microfluidics. ACS Nano, 2013; 131003133321000 DOI: 10.1021/nn4039063

Cite This Page:

American Chemical Society. "A mimic of 'good cholesterol' could treat cardiovascular, other diseases." ScienceDaily. ScienceDaily, 30 October 2013. <www.sciencedaily.com/releases/2013/10/131030104116.htm>.
American Chemical Society. (2013, October 30). A mimic of 'good cholesterol' could treat cardiovascular, other diseases. ScienceDaily. Retrieved March 1, 2015 from www.sciencedaily.com/releases/2013/10/131030104116.htm
American Chemical Society. "A mimic of 'good cholesterol' could treat cardiovascular, other diseases." ScienceDaily. www.sciencedaily.com/releases/2013/10/131030104116.htm (accessed March 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) — A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) — An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) — A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) — If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins