Featured Research

from universities, journals, and other organizations

Atherosclerosis in HIV patients linked to infection, not treatment

Date:
October 30, 2013
Source:
Columbia University's Mailman School of Public Health
Summary:
HIV infection, not antiretroviral therapy (ART), is associated with risk for atherosclerosis in patients with no history of smoking, particularly those infected for eight years or more. While a growing body of literature reports that HIV patients have higher risk for atherosclerotic disease and cardiovascular disease, it had been unknown whether HIV infection or ART are the responsible factors, and to what extent traditional cardiovascular risk factors, chiefly smoking, are responsible.

HIV infection, not antiretroviral therapy (ART), is associated with risk for atherosclerosis in patients with no history of smoking, particularly those infected for eight years or more. Results of the study led by Moïse Desvarieux, MD, PhD, at Columbia University's Mailman School of Public Health and at the Institut National de la Santé et de la Recherche Médicale (INSERM), are published in the latest issue of the journal AIDS.

Related Articles


A growing body of literature reports that HIV patients have higher risk for atherosclerotic disease and cardiovascular disease, but it has been unknown whether HIV infection or ART are the responsible factors, and to what extent traditional cardiovascular risk factors, chiefly smoking, are responsible. Previous studies on HIV, ART, and atherosclerosis had included smokers which made it difficult to disentangle the relationship. While previous studies had looked at specific inflammatory markers, none had studied the impact of inflammatory imbalance on atherosclerosis in the context of HIV. The authors hypothesized that the imbalance between pro- and anti-inflammatory markers would matter more for atherosclerosis than specific markers.

To explore the question, the researchers performed a retrospective study of 100 HIV-positive never-smokers for a minimum of 2 years, of whom half had never received ART and half had been treated with ART for at least 4 years, along with 50 HIV-negative controls. They looked for correlations between measures of carotid intima-media thickness, or c-IMT -- a measure of cardiovascular health -- and, in a first, inflammatory imbalance. Statistical adjustments were made for age, hypertension, and diabetes as well as HIV-infected patients with extremely low counts of lymphocytes, a type of white blood cell.

They found levels of c-IMT were significantly elevated in patients who had been infected for eight years or longer, even those not on ART. Longer time with the infection was also associated with weakened anti-inflammatory response profiles, irrespective of the pro-inflammatory response. "Lower anti-inflammatory response has been linked to increased risk for atherosclerosis, pointing to a potential mechanism within the context of HIV," notes Dr. Franck Boccara, professor of cardiology at Saint-Antoine hospital in Paris and a co-author of the study who will be initiating a 4-month sabbatical at Mailman this week.

The study does not determine whether HIV infection is a cause of atherosclerosis, the authors caution.

But it does contribute significantly by the careful choice of never-smokers and the hard-to-attain group of subjects with 2-year long HIV infection who had not yet required ART initiation, thus allowing for the study of HIV-infection alone. "We suggest that larger studies incorporate and validate the importance of inflammatory imbalance in occurrence of atherosclerosis" concludes Dr. Desvarieux, Mailman School associate professor of Epidemiology, who led the transnational multidisciplinary collaboration with scientists at INSERM and the Paris hospital systems.

About 1.1 million Americans live with HIV, according to the Centers for Disease Control. Globally, 34 million are infected, according to the World Health Organization.


Story Source:

The above story is based on materials provided by Columbia University's Mailman School of Public Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Moïse Desvarieux, Franck Boccara, Jean-Luc Meynard, Jean-Phillipe Bastard, Ziad Mallat, Beny Charbit, Ryan T. Demmer, Nabila Haddour, Soraya Fellahi, Alain Tedgui, Ariel Cohen, Jacqueline Capeau, Anders Boyd, Pierre-Marie Girard. Infection duration and inflammatory imbalance are associated with atherosclerotic risk in HIV-infected never-smokers independent of antiretroviral therapy. AIDS, 2013; 27 (16): 2603 DOI: 10.1097/QAD.0b013e3283634819

Cite This Page:

Columbia University's Mailman School of Public Health. "Atherosclerosis in HIV patients linked to infection, not treatment." ScienceDaily. ScienceDaily, 30 October 2013. <www.sciencedaily.com/releases/2013/10/131030142913.htm>.
Columbia University's Mailman School of Public Health. (2013, October 30). Atherosclerosis in HIV patients linked to infection, not treatment. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2013/10/131030142913.htm
Columbia University's Mailman School of Public Health. "Atherosclerosis in HIV patients linked to infection, not treatment." ScienceDaily. www.sciencedaily.com/releases/2013/10/131030142913.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) — The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins