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Learning and memory: How neurons activate PP1

Date:
November 4, 2013
Source:
Rockefeller University Press
Summary:
A study describes how neurons activate the protein PP1, providing key insights into the biology of learning and memory.

A study in The Journal of Cell Biology describes how neurons activate the protein PP1, providing key insights into the biology of learning and memory.

PP1 is known to be a key regulator of synaptic plasticity, the phenomenon in which neurons remodel their synaptic connections in order to store and relay information -- the foundation of learning and memory. But how PP1 is controlled has been unclear. Now, a team led by researchers from the LSU Health Science Center describes several mechanisms for PP1 regulation that close some major gaps in our understanding of its role in neuronal signaling.

Among the novel findings, the researchers describe how the neurotransmitter NMDA leads to activation of PP1. They show that, when NMDA activates neuronal synapses, it switches off an enzyme, Cdk5, that would otherwise inhibit PP1. This allows PP1 to activate itself and promote synaptic remodeling. In addition, the researchers suggest that, despite its name, a regulatory protein called inhibitor-2 helps promote PP1 activity in neurons. Together, these findings significantly extend our understanding of how PP1 is regulated in the context of synaptic plasticity.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hailong Hou, Lu Sun, Benjamin A. Siddoway, Ronald S. Petralia, Hongtian Yang, Hua Gu, Angus C. Nairn, and Houhui Xia. Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by Cdk5. J. Cell Biol., November 2013

Cite This Page:

Rockefeller University Press. "Learning and memory: How neurons activate PP1." ScienceDaily. ScienceDaily, 4 November 2013. <www.sciencedaily.com/releases/2013/11/131104123733.htm>.
Rockefeller University Press. (2013, November 4). Learning and memory: How neurons activate PP1. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2013/11/131104123733.htm
Rockefeller University Press. "Learning and memory: How neurons activate PP1." ScienceDaily. www.sciencedaily.com/releases/2013/11/131104123733.htm (accessed August 21, 2014).

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