Featured Research

from universities, journals, and other organizations

Closer to vaccine against C. difficile

Date:
November 4, 2013
Source:
University of Royal Holloway London
Summary:
A group of leading scientists from across Europe have launched a three-year project aimed at developing an oral vaccine against Clostridium difficile, an infection that kills 4,000 people a year (almost four-times more than MRSA) and for which there is currently no effective treatments.

A group of leading scientists from across Europe have launched a three-year project aimed at developing an oral vaccine against Clostridium difficile, an infection that kills around 4,000 people a year (almost four-times more than MRSA) and for which there is currently no effective treatments.

While normally harmless in healthy people, the C. difficile bacteria can be fatal when the natural bacteria of the gut are disrupted from antibiotic use. It is common among the elderly and infection rates are estimated to be as high as 50% in those whose hospital stays exceed four weeks.

Led by Royal Holloway University, the consortium has taken the novel approach of looking to produce a vaccine that can be taken orally, under the tongue, rather than via injection, by using harmless bacterial spores to carry antigens and boost immunity by targeting the protein needed for the infection to take hold.

"We believe that our approach to develop this vaccine will provide significantly greater protection against infection and relapse, than would have been achieved via injections. This method is also likely to inform the treatment of many other diseases," said Professor Simon Cutting from the School of Biological Sciences at Royal Holloway.

"C. difficile poses a major public health threat and there is an urgent need for protective vaccines. I am delighted to be coordinating this program with such a strong team of academic and industrial experts."

The project is funded by a European Union grant of approximately six million Euros, with the first clinical trials expected to start in the next 18 months.

The scientists are presenting the project to practitioners and pharmaceuticals from across the world today, at the 'Raising C. difficile Awareness' conference in North Carolina, USA and the BIO-Europe conference in Vienna, Austria.


Story Source:

The above story is based on materials provided by University of Royal Holloway London. Note: Materials may be edited for content and length.


Cite This Page:

University of Royal Holloway London. "Closer to vaccine against C. difficile." ScienceDaily. ScienceDaily, 4 November 2013. <www.sciencedaily.com/releases/2013/11/131104192248.htm>.
University of Royal Holloway London. (2013, November 4). Closer to vaccine against C. difficile. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2013/11/131104192248.htm
University of Royal Holloway London. "Closer to vaccine against C. difficile." ScienceDaily. www.sciencedaily.com/releases/2013/11/131104192248.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins