Featured Research

from universities, journals, and other organizations

Closer to vaccine against C. difficile

Date:
November 4, 2013
Source:
University of Royal Holloway London
Summary:
A group of leading scientists from across Europe have launched a three-year project aimed at developing an oral vaccine against Clostridium difficile, an infection that kills 4,000 people a year (almost four-times more than MRSA) and for which there is currently no effective treatments.

A group of leading scientists from across Europe have launched a three-year project aimed at developing an oral vaccine against Clostridium difficile, an infection that kills around 4,000 people a year (almost four-times more than MRSA) and for which there is currently no effective treatments.

Related Articles


While normally harmless in healthy people, the C. difficile bacteria can be fatal when the natural bacteria of the gut are disrupted from antibiotic use. It is common among the elderly and infection rates are estimated to be as high as 50% in those whose hospital stays exceed four weeks.

Led by Royal Holloway University, the consortium has taken the novel approach of looking to produce a vaccine that can be taken orally, under the tongue, rather than via injection, by using harmless bacterial spores to carry antigens and boost immunity by targeting the protein needed for the infection to take hold.

"We believe that our approach to develop this vaccine will provide significantly greater protection against infection and relapse, than would have been achieved via injections. This method is also likely to inform the treatment of many other diseases," said Professor Simon Cutting from the School of Biological Sciences at Royal Holloway.

"C. difficile poses a major public health threat and there is an urgent need for protective vaccines. I am delighted to be coordinating this program with such a strong team of academic and industrial experts."

The project is funded by a European Union grant of approximately six million Euros, with the first clinical trials expected to start in the next 18 months.

The scientists are presenting the project to practitioners and pharmaceuticals from across the world today, at the 'Raising C. difficile Awareness' conference in North Carolina, USA and the BIO-Europe conference in Vienna, Austria.


Story Source:

The above story is based on materials provided by University of Royal Holloway London. Note: Materials may be edited for content and length.


Cite This Page:

University of Royal Holloway London. "Closer to vaccine against C. difficile." ScienceDaily. ScienceDaily, 4 November 2013. <www.sciencedaily.com/releases/2013/11/131104192248.htm>.
University of Royal Holloway London. (2013, November 4). Closer to vaccine against C. difficile. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2013/11/131104192248.htm
University of Royal Holloway London. "Closer to vaccine against C. difficile." ScienceDaily. www.sciencedaily.com/releases/2013/11/131104192248.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins