Featured Research

from universities, journals, and other organizations

Nanotech drug smugglers

Date:
November 11, 2013
Source:
Inderscience
Summary:
Tiny capsules of carbon are invisible to the chemical gatekeeper that flushes potentially harmful substances out of our bodies' cells, according to new research. The finding might allow a pharmaceutical to be smuggled into cells even when multidrug resistance has evolved.

Tiny capsules of carbon are invisible to the chemical gatekeeper that flushes potentially harmful substances out of our bodies' cells, according to research published in the International Journal of Computational Biology and Drug Design. The finding might allow a pharmaceutical to be smuggled into cells even when multidrug resistance has evolved.

Related Articles


Sergey Shityakov and Carola Förster of the University of Würzburg, Germany, explain that the protein, P-glycoprotein, acts as a gatekeeper, flushing out potentially harmful chemicals that enter the body as well as the naturally-occurring products of metabolism. The protein thus plays a vital role in the health of the cell. Unfortunately, it is a strong modulator of chemical traffic across the cell membrane that it can also prevent therapeutic agents from working properly, flushing them out as if they were simply harmful compounds. This process underpins the emergence of multidrug resistance in several diseases, including various forms of cancer.

Shityakov and Förster have revealed recently that if there were a way to mask the presence of the therapeutic agent, later the gatekeeper would not see them as "unwanted molecular entities" to be eradicated, and therefore, these drugs might be able to carry out their job unhindered and so overcome drug resistance. However, some of the chemical substances have turned to the realm of nanotechnology, and in particular, tiny capsules of carbon atoms known as fullerenes and the related molecules, the carbon nanotubes. The latter synthetic materials are not recognized by P-glycoprotein and so can penetrate lipid membranes moving freely in and out of cells.

The team has investigated whether it might be possible to carry drug molecules inside these nanocapsules so that they are unimpeded by interactions with P-glycoprotein or other receptors. They used high-power computational techniques to demonstrate that carbon nanotubes are not able to "dock" with the gatekeeper protein. Moreover, their analysis of the binding energy needed to push a nanotube into P-glycoprotein shows that the process is unfavourable and so rather than "docking" with this gatekeeper protein these peculiar materials are repelled by it to maintain the interior of the cell and so have the potential to act as a molecular drug smuggler.


Story Source:

The above story is based on materials provided by Inderscience. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sergey Shityakov, Carola Förster. Multidrug resistance protein P-gp interaction with nanoparticles (fullerenes and carbon nanotube) to assess their drug delivery potential: a theoretical molecular docking study. International Journal of Computational Biology and Drug Design, 2013; 6 (4): 343 DOI: 10.1504/IJCBDD.2013.056801

Cite This Page:

Inderscience. "Nanotech drug smugglers." ScienceDaily. ScienceDaily, 11 November 2013. <www.sciencedaily.com/releases/2013/11/131111112534.htm>.
Inderscience. (2013, November 11). Nanotech drug smugglers. ScienceDaily. Retrieved April 21, 2015 from www.sciencedaily.com/releases/2013/11/131111112534.htm
Inderscience. "Nanotech drug smugglers." ScienceDaily. www.sciencedaily.com/releases/2013/11/131111112534.htm (accessed April 21, 2015).

Share This


More From ScienceDaily



More Matter & Energy News

Tuesday, April 21, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Humanoid Robot Can Recognise and Interact With People

Humanoid Robot Can Recognise and Interact With People

Reuters - Innovations Video Online (Apr. 20, 2015) — An ultra-realistic humanoid robot called &apos;Han&apos; recognises and interprets people&apos;s facial expressions and can even hold simple conversations. Developers Hanson Robotics hope androids like Han could have uses in hospitality and health care industries where face-to-face communication is vital. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Drones and Health Apps at Santiago's "Robotics Day"

Drones and Health Apps at Santiago's "Robotics Day"

AFP (Apr. 20, 2015) — Latin American robotics experts gather in Santiago, Chile for "Robotics Day". Video provided by AFP
Powered by NewsLook.com
Japan Humanoid Robot Receives Customers at Department Store

Japan Humanoid Robot Receives Customers at Department Store

AFP (Apr. 20, 2015) — She can smile, she can sing and she can give you guidance at one of the most upscale department stores in Tokyo...a female-looking humanoid makes her debut as a receptionist Video provided by AFP
Powered by NewsLook.com
Pee-Power Toilet to Light Up Disaster Zones

Pee-Power Toilet to Light Up Disaster Zones

Reuters - Innovations Video Online (Apr. 20, 2015) — Students and staff are being asked to use a prototype urinal to &apos;donate&apos; urine to fuel microbial fuel cell (MFC) stacks that generate electricity to power lighting. The developers hope the pee-power technology will light toilet cubicles in refugee camps, where women are often at risk of assault in poorly lit sanitation areas. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins