Featured Research

from universities, journals, and other organizations

Gene speeds kidney disease progression, failure in blacks, regardless of diabetes status

Date:
November 11, 2013
Source:
University of Pennsylvania School of Medicine
Summary:
A large study found that African Americans with the APOL1 gene variant experience faster progression of chronic kidney disease and have a significantly increased risk of kidney failure, regardless of their diabetes status.

A large study co-led by Penn Medicine published this week in the New England Journal of Medicine found that African Americans with the APOL1 gene variant experience faster progression of chronic kidney disease (CKD) and have a significantly increased risk of kidney failure, regardless of their diabetes status.

Related Articles


The findings, published in conjunction with a presentation at the American Society of Nephrology annual meeting, come from the two largest prospective National Institutes of Health-funded study cohorts of nearly 5,000 individuals with kidney disease: the African-American Study of Kidney Disease and Hypertension (AASK) and the Chronic Renal Insufficiency Cohort (CRIC) study.

Those studies involve institutions from across the country, including the Perelman School of Medicine at the University of Pennsylvania, which houses the Scientific and Data Coordinating Center (SDCC) for the CRIC study, led by Harold I. Feldman, MD, MSCE who also chairs the study's national Steering Committee.

Dr. Feldman, director of Penn's Center for Clinical Epidemiology and Biostatistics (CCEB) and chair of its Department of Biostatistics and Epidemiology (DBE) and Amanda H. Anderson, PhD, MPH, assistant professor of Epidemiology in the DBE, are co-authors.

Past studies have found that APOL1 risk variants are associated with a 40 percent increased risk of CKD in African Americans compared to whites. Many, however, focused on people without diabetes. And for those that did focus on diabetes, the findings were inconsistent.

"This was a surprising finding for the group that helps answer another big piece of the puzzle," said Anderson. "In previous literature, there has been more of a definitive picture of blacks without diabetes, but here we demonstrated that APOL1 gene variants also play a role in the development of kidney failure in those with diabetes." Such information helps researchers better understand why African-Americans are four times more likely to develop kidney failure than whites, regardless of the cause of failure.

It also helps explain, in part, the faster progression toward kidney failure observed in blacks with CKD, she added.

In the AASK study, which enrolled only African Americans, kidney failure occurred in 58 percent of participants in the APOL1 risk group and 37 percent in the APOL1 non-risk group. In the CRIC study, kidney function decline was greater among African Americans in the APOL1 risk group, but it was similar among African Americans in the APOL1 non-risk group and European Americans.

The findings provide direct evidence that African Americans with established CKD have a faster kidney function decline and increased rates of kidney failure compared with whites, and that APOL1risk variants increase CKD progression in African Americans.

Senior authors include researchers from University of Maryland School of Medicine, Johns Hopkins Bloomberg School of Public and Georgetown University of School of Medicine.

"Knowing the role of these variants may lead to screening tests and new preventive measures for those at risk, such as earlier treatment," said Anderson.


Story Source:

The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Afshin Parsa, W.H. Linda Kao, Dawei Xie, Brad C. Astor, Man Li, Chi-Yuan Hsu, Harold I. Feldman, Rulan S. Parekh, John W. Kusek, Tom H. Greene, Jeffrey C. Fink, Amanda H. Anderson, Michael J. Choi, Jackson T. Wright, James P. Lash, Barry I. Freedman, Akinlolu Ojo, Cheryl A. Winkler, Dominic S. Raj, Jeffrey B. Kopp, Jiang He, Nancy G. Jensvold, Kaixiang Tao, Michael S. Lipkowitz, Lawrence J. Appel. APOL1Risk Variants, Race, and Progression of Chronic Kidney Disease. New England Journal of Medicine, 2013; 131109063041006 DOI: 10.1056/NEJMoa1310345

Cite This Page:

University of Pennsylvania School of Medicine. "Gene speeds kidney disease progression, failure in blacks, regardless of diabetes status." ScienceDaily. ScienceDaily, 11 November 2013. <www.sciencedaily.com/releases/2013/11/131111122111.htm>.
University of Pennsylvania School of Medicine. (2013, November 11). Gene speeds kidney disease progression, failure in blacks, regardless of diabetes status. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2013/11/131111122111.htm
University of Pennsylvania School of Medicine. "Gene speeds kidney disease progression, failure in blacks, regardless of diabetes status." ScienceDaily. www.sciencedaily.com/releases/2013/11/131111122111.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Rural India's Low-Cost Sanitary Pad Revolution

Rural India's Low-Cost Sanitary Pad Revolution

AFP (Nov. 28, 2014) — One man hopes his invention -– a machine that produces cheap sanitary pads –- will help empower Indian women. Duration: 01:51 Video provided by AFP
Powered by NewsLook.com
Research on Bats Could Help Develop Drugs Against Ebola

Research on Bats Could Help Develop Drugs Against Ebola

AFP (Nov. 28, 2014) — In Africa's only biosafety level 4 laboratory, scientists have been carrying out experiments on bats to understand how virus like Ebola are being transmitted, and how some of them resist to it. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
WHO Says Male Ebola Survivors Should Abstain From Sex

WHO Says Male Ebola Survivors Should Abstain From Sex

Newsy (Nov. 28, 2014) — WHO cites four studies that say Ebola can still be detected in semen up to 82 days after the onset of symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins