Featured Research

from universities, journals, and other organizations

First genetic mutations linked to atopic dermatitis identified in African-American children

Date:
November 11, 2013
Source:
University of Pennsylvania School of Medicine
Summary:
Two specific genetic variations in people of African descent are responsible for persistent atopic dermatitis, an itchy, inflammatory form of the skin disorder eczema. A new report found that loss-of-function mutations to Filaggrin-2, a gene that creates a protein responsible for retaining moisture and protecting the skin from environmental irritants, were associated with atopic dermatitis in African-American children.

Two specific genetic variations in people of African descent are responsible for persistent atopic dermatitis (AD), an itchy, inflammatory form of the skin disorder eczema. A new report by researchers in the Perelman School of Medicine at the University of Pennsylvania found that loss-of-function mutations to Filaggrin-2 (FLG2), a gene that creates a protein responsible for retaining moisture and protecting the skin from environmental irritants, were associated with atopic dermatitis in African American children. The study, the first report to deduce the mechanism responsible for the persistent form of the condition in African American children, was published in the Journal of Allergy and Clinical Immunology.

Related Articles


Nearly half of people with atopic dermatitis in the United States are African-American children. Previous studies have shown than those of African descent do not usually carry a mutation to the filaggrin gene (FLG) that has been associated with the risk of onset and persistence of AD in those of European and Asian ancestry.

"This finding helps confirm that skin barrier proteins are important in Atopic Dermatitis for people of all ancestries," said lead study author David Margolis, MD, PhD, professor of Dermatology and Epidemiology. "It could also lead to a way to determine which children are most likely to have persistent flare ups throughout their lives."

The team evaluated DNA from 299 African American children, none of whom had experienced skin free of symptoms of AD while not on medication in the previous 6 months. Within the group, researchers discovered that children with either one of two FLG2 mutations -- rs12568784 or rs16833974 -- were more than 50 percent more likely to have persistent AD than those without the mutations.

Future research will work to better understand mutations of FLG2 and determine if they result in functional changes to the FLG2 protein. In addition, the team is continuing research into mechanisms that may turn off the immune response to irritants that pass through the dysfunctional skin barrier and incite the inflammatory response seen in AD.


Story Source:

The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. David J. Margolis, Jayanta Gupta, Andrea J. Apter, Tapan Ganguly, Ole Hoffstad, Maryte Papadopoulos, Tim R. Rebbeck, Nandita Mitra. Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects. Journal of Allergy and Clinical Immunology, 2013; DOI: 10.1016/j.jaci.2013.09.015

Cite This Page:

University of Pennsylvania School of Medicine. "First genetic mutations linked to atopic dermatitis identified in African-American children." ScienceDaily. ScienceDaily, 11 November 2013. <www.sciencedaily.com/releases/2013/11/131111140503.htm>.
University of Pennsylvania School of Medicine. (2013, November 11). First genetic mutations linked to atopic dermatitis identified in African-American children. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2013/11/131111140503.htm
University of Pennsylvania School of Medicine. "First genetic mutations linked to atopic dermatitis identified in African-American children." ScienceDaily. www.sciencedaily.com/releases/2013/11/131111140503.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Diné Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins