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Can eyes help diagnose Alzheimer's disease?

Date:
November 13, 2013
Source:
Georgetown University Medical Center
Summary:
An international team of researchers studying the link between vision loss and Alzheimer's disease report that the loss of a particular layer of retinal cells not previously investigated may provide a new way to track disease progression. "The retina is an extension of the brain so it makes sense to see if the same pathologic processes found in an Alzheimer's brain are also found in the eye," they explain.

An international team of researchers studying the link between vision loss and Alzheimer's disease report that the loss of a particular layer of retinal cells not previously investigated may reveal the disease's presence and provide a new way to track disease progression.

The researchers, from Georgetown University Medical Center (GUMC) and the University of Hong Kong, examined retinas from the eyes of mice genetically engineered to develop Alzheimer's disease (AD). They presented their findings today at Neuroscience 2013, the annual meeting of the Society for Neuroscience.

"The retina is an extension of the brain so it makes sense to see if the same pathologic processes found in an Alzheimer's brain are also found in the eye," explains R. Scott Turner, MD, PhD, director of the Memory Disorders Program at GUMC and the only U.S. author on the study. "We know there's an association between glaucoma and Alzheimer's in that both are characterized by loss of neurons, but the mechanisms are not clear."

Turner says many researchers increasingly view glaucoma as a neurodegenerative disorder similar to AD.

Most of the research to date examining the relationship between glaucoma and Alzheimer's focused on the retinal ganglion cell layer, which transmits visual information via the optic nerve into the brain. Before that transmission happens, though, the retinal ganglion cells receive information from another layer in the retina called the inner nuclear layer.

In their study, the researchers looked at the thickness of the retina, including the inner nuclear layer (not previously study in this setting) and the retinal ganglion cell layer. They found a significant loss of thickness in both. The inner nuclear layer had a 37 percent loss of neurons and the retinal ganglion cell layer a 49 percent loss, compared with healthy, age-matched control mice.

In humans, the structure and thickness of the retina can be readily measured using optical coherence tomography. Turner says this new tool is increasing finding applications in research and clinical care.

"This study suggests another path forward in understanding the disease process and could lead to new ways to diagnose or predict Alzheimer's that could be as simple as looking into the eyes," Turner says. "Parallel disease mechanisms suggest that new treatments developed for Alzheimer's may also be useful for glaucoma."


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Georgetown University Medical Center. "Can eyes help diagnose Alzheimer's disease?." ScienceDaily. ScienceDaily, 13 November 2013. <www.sciencedaily.com/releases/2013/11/131113125843.htm>.
Georgetown University Medical Center. (2013, November 13). Can eyes help diagnose Alzheimer's disease?. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/11/131113125843.htm
Georgetown University Medical Center. "Can eyes help diagnose Alzheimer's disease?." ScienceDaily. www.sciencedaily.com/releases/2013/11/131113125843.htm (accessed July 23, 2014).

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