Featured Research

from universities, journals, and other organizations

Topical treatment for psoriasis targets deeper layers of the skin, improves healing

Date:
November 14, 2013
Source:
American Association of Pharmaceutical Scientists (AAPS)
Summary:
A novel combination anti-psoriasis therapy has potential for superior and longer-lasting therapeutic effects than current topical treatments by targeting genetic abnormalities in deeper layers of the skin.

A novel combination anti-psoriasis therapy has potential for superior and longer-lasting therapeutic effects than current topical treatments by targeting genetic abnormalities in deeper layers of the skin. This research is being presented at the 2013 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting, in San Antonio, Nov. 10-14.

Psoriasis is a chronic autoimmune skin disorder that significantly impacts a patient's quality of life. The overactive immune system triggers skin cells to grow rapidly and then form psoriatic plaques. Approximately 7.5 million people have psoriasis in the United States, according to the American Academy of Dermatology.

Mandip Sachdeva, Ph.D., and Srujan Marepally, Ph.D., along with their colleagues from Florida Agricultural and Mechanical University, developed a topical formulation of a gene-regulating nanoparticle (Dual-F-NALP) carrying two nucleic acids, which controls the skin cells from developing psoriatic plaques and suppresses inflammation.

To test the effectiveness of their formulation they used the Psoriasis Area and Severity Index (PASI), a clinical scoring system from 0-4, with four being the most severe. Before treatment, the psoriatic plaque-like mouse model had a score of four, with increased inflammation and skin thickening, which confirmed their impaired natural healing. Their PASI score decreased to zero after five days of Dual-F-NALP treatment.

"Our goal was to reconstitute the balance between skin and immune system in psoriatic plaques," said Sachdeva. "Since this therapy targets the vicious cycle within skin over activation and immune hypersensitivity in the deeper dermal layers, the chance for relapse of the disease is less. We anticipate a once-a-day application with the therapeutic effects lasting longer than current topical treatment, which need to be applied multiple times a day. It is possible that this increased effectiveness will translate to early recovery from psoriatic lesions, and that is an area we will be examining in our future work."

Sachdeva compared their formulation with Tacrolimus, an existing topical ointment used to treat psoriasis. Since Tacrolimus is an immunosuppressant, a main side effect is redness and itchiness around the application area and long-term use is avoided because it has been linked to skin cancer and lymphoma.

The next stage of Sachdeva's research is to test in humanized mouse models with psoriasis plaque and conduct toxicology tests.


Story Source:

The above story is based on materials provided by American Association of Pharmaceutical Scientists (AAPS). Note: Materials may be edited for content and length.


Cite This Page:

American Association of Pharmaceutical Scientists (AAPS). "Topical treatment for psoriasis targets deeper layers of the skin, improves healing." ScienceDaily. ScienceDaily, 14 November 2013. <www.sciencedaily.com/releases/2013/11/131114101917.htm>.
American Association of Pharmaceutical Scientists (AAPS). (2013, November 14). Topical treatment for psoriasis targets deeper layers of the skin, improves healing. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2013/11/131114101917.htm
American Association of Pharmaceutical Scientists (AAPS). "Topical treatment for psoriasis targets deeper layers of the skin, improves healing." ScienceDaily. www.sciencedaily.com/releases/2013/11/131114101917.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins