Featured Research

from universities, journals, and other organizations

Manipulation of protein could help stop spread of cancer cells

Date:
November 18, 2013
Source:
University of Bristol
Summary:
Understanding how and why cancer cells move away from their original location is important to find ways to stop the spread of the disease. New findings reveal how a protein, called "PRH," is normally able to prevent cells from unnecessary migration. It is likely that this protein is less effective in cancer cells allowing the cells to venture away.

Understanding how and why cancer cells move away from their original location is important to find ways to stop the spread of the disease. New findings, published in the Nature journal Oncogene, reveal how a protein, called 'PRH', is normally able to prevent cells from unnecessary migration. It is likely that this protein is less effective in cancer cells allowing the cells to venture away.

Related Articles


Researchers from the Universities of Bristol and Birmingham, who have been studying breast and prostate cancer cells, show how manipulating PRH's levels in cancer cells can hinder their ability to penetrate into neighbouring environments, potentially preventing them from entering nearby blood vessels. The findings could lead to new ways of combating the spread of the disease in multiple cancers.

PRH belongs to a group of proteins known as 'transcription factors', meaning its role is to interact with DNA to 'switch' particular genes 'on' or 'off'. Scientists have been aware of PRHs' role in controlling cell growth and specification for some time. For example, it is essential for the healthy development of foetuses but this is the first time PRH has been implicated in the movement of cancer cells.

After growing normal and cancerous breast and prostate cells in the laboratory the team used genetic techniques to either increase or decrease PRH levels. The team then examined the cells and found that without PRH, the cells migrated much faster, and were able to invade through a porous gel more efficiently.

The researchers show that PRH is responsible for 'switching on' another protein called Endoglin, which has also been shown to be important in cell migration. The low levels of PRH found in cancer cells leads to low levels of Endoglin, and therefore results in increased cell migration and enhanced invasion. Interestingly, adding additional Endoglin to cancer cells with no PRH was sufficient to reduce their migration and invasion.

Dr Kevin Gaston, co-author of the study and Reader at Bristol's School of Biochemistry in the Faculty of Medical and Veterinary Sciences, said: "It is not simply the growth of cancers but their ability to move to multiple locations in the body that makes the disease so deadly. PRH transcription factor inhibits the migration of normal and cancerous breast cells and prostate cells and this represents a novel mechanism that could be important in multiple cancers."

Dr Padma-Sheela Jayaraman, co-author of the study and Senior Lecturer at the University of Birmingham, said: "Here we show for the first time that the PRH transcription factor inhibits the migration of normal and cancerous breast cells and prostate cells. This work reveals exciting new targets for future translational research."

Importantly, as this mechanism appears to apply to more than one cancer type, PRH regulation of Endoglin may represent a novel method for controlling migration that could potentially be exploited to treat multiple cancers.

Katherine Woods, Research Information Manager at Breast Cancer Campaign, said: "This interesting work has brought us another step closer to understanding how breast cancer cells move and spread around the body, and closer to knowing how we could stop this spread to help women outlive the disease. This research is all the more valuable because it could have implications for other cancers such as prostate and thyroid cancer, and some leukemias."


Story Source:

The above story is based on materials provided by University of Bristol. Note: Materials may be edited for content and length.


Journal Reference:

  1. R M Kershaw, Y H Siddiqui, D Roberts, P-S Jayaraman, K Gaston. PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin. Oncogene, 2013; DOI: 10.1038/onc.2013.496

Cite This Page:

University of Bristol. "Manipulation of protein could help stop spread of cancer cells." ScienceDaily. ScienceDaily, 18 November 2013. <www.sciencedaily.com/releases/2013/11/131118102630.htm>.
University of Bristol. (2013, November 18). Manipulation of protein could help stop spread of cancer cells. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2013/11/131118102630.htm
University of Bristol. "Manipulation of protein could help stop spread of cancer cells." ScienceDaily. www.sciencedaily.com/releases/2013/11/131118102630.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Fauci Says Ebola Risk in US "essentially Zero"

Fauci Says Ebola Risk in US "essentially Zero"

AP (Oct. 30, 2014) NIAID Director Anthony Fauci said the risk of Ebola becoming an epidemic in the U.S. is essentially zero Thursday at the Washington Ideas Forum. He also said an Ebola vaccine will be tested in West Africa in the next few months. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Nurse Defies Ebola Quarantine With Bike Ride

Nurse Defies Ebola Quarantine With Bike Ride

AP (Oct. 30, 2014) A nurse who vowed to defy Maine's voluntary quarantine for health care workers who treated Ebola patients followed through on her promise Thursday, leaving her home for an hour-long bike ride. (Oct. 30) Video provided by AP
Powered by NewsLook.com
Microsoft Launches Fitness Band After Accidental Reveal

Microsoft Launches Fitness Band After Accidental Reveal

Newsy (Oct. 30, 2014) Microsoft accidentally revealed its upcoming fitness band on Wednesday, so the company went ahead and announced it. Video provided by Newsy
Powered by NewsLook.com
Studying Effects of Music on Dementia Patients

Studying Effects of Music on Dementia Patients

AP (Oct. 30, 2014) The University of Wisconsin-Milwaukee is studying the popular Music and Memory program to see if music, which helps improve the mood of Alzheimer's patients, can also reduce the use of prescription drugs for those suffering from dementia. (Oct. 30) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins