Featured Research

from universities, journals, and other organizations

Linking risk factors, disease origins in breast cancer

Date:
November 20, 2013
Source:
Landes Bioscience
Summary:
Researchers have found that epigenetic changes to DNA are associated with aging in disease-free breast tissues and are further altered in breast tumors. Epigenetic changes describe heritable alterations caused by mechanisms other than by changes in DNA sequence. The discovery illustrates how cancer and aging are tightly interconnected processes by identifying epigenetic alterations present in the normal aging breast that may increase disease risk in cancer-free individuals.

Researchers from the Geisel School of Medicine at Dartmouth have found that epigenetic changes to DNA are associated with aging in disease-free breast tissues and are further altered in breast tumors. Epigenetic changes describe heritable alterations caused by mechanisms other than by changes in DNA sequence. The discovery, published in the February 2014 issue of Epigenetics, illustrates how cancer and aging are tightly interconnected processes by identifying epigenetic alterations present in the normal aging breast that may increase disease risk in cancer-free individuals.

Related Articles


The epigenetic changes examined highlight different patterns in DNA methylation, which involves the chemical modification of DNA and acts in the control of gene expression. While DNA methylation is a normal and necessary epigenetic process, breast tumors exhibit altered methylation patterns compared to normal breast tissue. Accordingly, atypical DNA methylation marks are recognized to precede cancer initiation.

For the study, the researchers leveraged publicly available genome-wide methylation data on disease-free breast tissues and identified consistent methylation alterations associated with the aging process across multiple populations. The levels of methylation in normal tissues were then compared to breast tumor tissues where age-related changes were further altered in breast tumors. Their data suggests that there may be common genomic regions that are particularly susceptible to changes in DNA methylation over time in disease-free breast tissue (or that these changes are selected for) on the path to development of cancer.

Although age is the strongest demographic risk factor for breast cancer, the mechanisms underlying how age increases a woman's risk for the development of disease are incompletely characterized. Emerging literature has demonstrated that aging can have profound effects on DNA methylation patterns that reflect an accumulation of exposures. Hence, the study extends the understanding of the biological mechanisms through which an established breast cancer risk factor, such as age, contributes to carcinogenesis.


Story Source:

The above story is based on materials provided by Landes Bioscience. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kevin C Johnson, Devin C Koestler, Chao Cheng, Brock C Christensen. Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation. Epigenetics, 2014; 9 (2) DOI: 10.4161/epi.27015

Cite This Page:

Landes Bioscience. "Linking risk factors, disease origins in breast cancer." ScienceDaily. ScienceDaily, 20 November 2013. <www.sciencedaily.com/releases/2013/11/131120103617.htm>.
Landes Bioscience. (2013, November 20). Linking risk factors, disease origins in breast cancer. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2013/11/131120103617.htm
Landes Bioscience. "Linking risk factors, disease origins in breast cancer." ScienceDaily. www.sciencedaily.com/releases/2013/11/131120103617.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins