Featured Research

from universities, journals, and other organizations

Linking risk factors, disease origins in breast cancer

Date:
November 20, 2013
Source:
Landes Bioscience
Summary:
Researchers have found that epigenetic changes to DNA are associated with aging in disease-free breast tissues and are further altered in breast tumors. Epigenetic changes describe heritable alterations caused by mechanisms other than by changes in DNA sequence. The discovery illustrates how cancer and aging are tightly interconnected processes by identifying epigenetic alterations present in the normal aging breast that may increase disease risk in cancer-free individuals.

Researchers from the Geisel School of Medicine at Dartmouth have found that epigenetic changes to DNA are associated with aging in disease-free breast tissues and are further altered in breast tumors. Epigenetic changes describe heritable alterations caused by mechanisms other than by changes in DNA sequence. The discovery, published in the February 2014 issue of Epigenetics, illustrates how cancer and aging are tightly interconnected processes by identifying epigenetic alterations present in the normal aging breast that may increase disease risk in cancer-free individuals.

Related Articles


The epigenetic changes examined highlight different patterns in DNA methylation, which involves the chemical modification of DNA and acts in the control of gene expression. While DNA methylation is a normal and necessary epigenetic process, breast tumors exhibit altered methylation patterns compared to normal breast tissue. Accordingly, atypical DNA methylation marks are recognized to precede cancer initiation.

For the study, the researchers leveraged publicly available genome-wide methylation data on disease-free breast tissues and identified consistent methylation alterations associated with the aging process across multiple populations. The levels of methylation in normal tissues were then compared to breast tumor tissues where age-related changes were further altered in breast tumors. Their data suggests that there may be common genomic regions that are particularly susceptible to changes in DNA methylation over time in disease-free breast tissue (or that these changes are selected for) on the path to development of cancer.

Although age is the strongest demographic risk factor for breast cancer, the mechanisms underlying how age increases a woman's risk for the development of disease are incompletely characterized. Emerging literature has demonstrated that aging can have profound effects on DNA methylation patterns that reflect an accumulation of exposures. Hence, the study extends the understanding of the biological mechanisms through which an established breast cancer risk factor, such as age, contributes to carcinogenesis.


Story Source:

The above story is based on materials provided by Landes Bioscience. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kevin C Johnson, Devin C Koestler, Chao Cheng, Brock C Christensen. Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation. Epigenetics, 2014; 9 (2) DOI: 10.4161/epi.27015

Cite This Page:

Landes Bioscience. "Linking risk factors, disease origins in breast cancer." ScienceDaily. ScienceDaily, 20 November 2013. <www.sciencedaily.com/releases/2013/11/131120103617.htm>.
Landes Bioscience. (2013, November 20). Linking risk factors, disease origins in breast cancer. ScienceDaily. Retrieved April 25, 2015 from www.sciencedaily.com/releases/2013/11/131120103617.htm
Landes Bioscience. "Linking risk factors, disease origins in breast cancer." ScienceDaily. www.sciencedaily.com/releases/2013/11/131120103617.htm (accessed April 25, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

85 Killed in Niger by Meningitis Since Start of Year

85 Killed in Niger by Meningitis Since Start of Year

AFP (Apr. 24, 2015) A meningitis outbreak in Niger has killed 85 people since the start of the year prompting authorities to close schools in the capital Niamey until Monday. Video provided by AFP
Powered by NewsLook.com
C-Section Births a Trend in Brazil

C-Section Births a Trend in Brazil

AFP (Apr. 24, 2015) More than half of Brazil&apos;s babies are born via cesarean section, as mothers and doctors opt for a faster and less painful experience despite the health risks. Duration: 02:02 Video provided by AFP
Powered by NewsLook.com
Anti-Malaria Jab Hope

Anti-Malaria Jab Hope

Reuters - News Video Online (Apr. 24, 2015) The world&apos;s first anti-malaria vaccine could get the go-ahead for use in Africa from October if approved by international regulators. Paul Chapman reports. Video provided by Reuters
Powered by NewsLook.com
3D Food Printing: The Meal of the Future?

3D Food Printing: The Meal of the Future?

AP (Apr. 23, 2015) Developers of 3D food printing hope the culinary technology will revolutionize the way we cook and eat. (April 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins