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Key protein responsible for controlling communication between brain cells identified

Date:
November 27, 2013
Source:
University of Bristol
Summary:
Scientists are a step closer to understanding how some of the brain's 100 billion nerve cells co-ordinate their communication.

An image of a hippocampal neuron stained for endogenous RIM1 and SUMO. RIM1 is in red and SUMO in green.
Credit: University of Bristol

Scientists are a step closer to understanding how some of the brain's 100 billion nerve cells co-ordinate their communication. The study is published in the journal Cell Reports.

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The University of Bristol research team investigated some of the chemical processes that underpin how brain cells co-ordinate their communication. Defects in this communication are associated with disorders such as epilepsy, autism and schizophrenia, and therefore these findings could lead to the development of novel neurological therapies.

Neurons in the brain communicate with each other using chemicals called neurotransmitters. This release of neurotransmitter from neurons is tightly controlled by many different proteins inside the neuron. These proteins interact with each other to ensure that neurotransmitter is only released when necessary. Although the mechanisms that control this release have been extensively studied, the processes that co-ordinate how and when the component proteins interact is not fully understood.

The School of Biochemistry researchers have now discovered that one of these proteins called 'RIM1α' is modified by a small protein named 'SUMO' which attaches to a specific region in RIM1α. This process acts as a 'molecular switch' which is required for normal neurotransmitter release.

Jeremy Henley, Professor of Molecular Neuroscience in the University's Faculty of Medical and Veterinary Sciences and the study's lead author, said: "These findings are important as they show that SUMO modification plays a vital and previously unsuspected role in normal brain function."

The research builds on the team's earlier work that identified a group of proteins in the brain responsible for protecting nerve cells from damage and could be used in future for therapies for stroke and other brain diseases.


Story Source:

The above story is based on materials provided by University of Bristol. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fatima Girach, Tim J. Craig, Daniel L. Rocca, Jeremy M. Henley. RIM1α SUMOylation Is Required for Fast Synaptic Vesicle Exocytosis. Cell Reports, 2013; DOI: 10.1016/j.celrep.2013.10.039

Cite This Page:

University of Bristol. "Key protein responsible for controlling communication between brain cells identified." ScienceDaily. ScienceDaily, 27 November 2013. <www.sciencedaily.com/releases/2013/11/131127122409.htm>.
University of Bristol. (2013, November 27). Key protein responsible for controlling communication between brain cells identified. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2013/11/131127122409.htm
University of Bristol. "Key protein responsible for controlling communication between brain cells identified." ScienceDaily. www.sciencedaily.com/releases/2013/11/131127122409.htm (accessed March 27, 2015).

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