Featured Research

from universities, journals, and other organizations

Oxygen levels affect effectiveness of anti-inflammatory therapies

Date:
December 2, 2013
Source:
Federation of American Societies for Experimental Biology
Summary:
A new research discovery yields an important clue toward helping curb runaway inflammation. Oxygen levels play a critical role in determining the severity of the inflammatory response and ultimately the effectiveness of anti-inflammatory drugs. This research could have significant future benefits for patients with severe asthma, COPD, rheumatoid arthritis, pulmonary fibrosis and coronary artery disease.

A new research discovery published in the December 2013 issue of the Journal of Leukocyte Biology yields an important clue toward helping curb runaway inflammation. Oxygen levels play a critical role in determining the severity of the inflammatory response and ultimately the effectiveness of anti-inflammatory drugs. This research could have significant future benefits for patients with severe asthma, COPD, rheumatoid arthritis, pulmonary fibrosis and coronary artery disease.

Related Articles


According to John Marwick from the MRC Centre for Inflammation Research at The Queen's Medical Research Institute at the University of Edinburgh Medical School in Edinburgh, Scotland, and a researcher involved in the work, "Inflammatory diseases contribute to countless deaths and suffering of people. We hope that by understanding the processes involved in inflammation we will herald the arrival of new and targeted anti-inflammatory drugs that have fewer side effects than what is currently available."

To make this discovery, researchers isolated neutrophils, the immune cells that are responsible for acute inflammation, from the blood of healthy volunteers and incubated them in different levels of oxygen. They then added substances that are usually present at sites of inflammation in humans, both with and without anti-inflammatory glucocorticoid drugs and studied what effect these factors had on neutrophil lifespan. They found that the oxygen levels altered the effectiveness of the drugs, which suggests that these drugs may be less effective for some diseases than they are for others. Future areas of research include developing a deeper understanding of exactly how these drugs work under different conditions to ultimately help with development of new, better tolerated anti-inflammatory therapies.

"This report may shed light on why some people respond better to anti-inflammatory drugs than others, and it suggests that a one size fits all strategy to anti-inflammatory drugs may be overly simplistic. This work could be a foundation to identifying ways to tailor anti-inflammatory agents to specifically treat different diseases," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. A. Marwick, D. A. Dorward, C. D. Lucas, K. O. Jones, T. A. Sheldrake, S. Fox, C. Ward, J. Murray, M. Brittan, N. Hirani, R. Duffin, I. Dransfield, C. Haslett, A. G. Rossi. Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments. Journal of Leukocyte Biology, 2013; 94 (6): 1285 DOI: 10.1189/jlb.0912462

Cite This Page:

Federation of American Societies for Experimental Biology. "Oxygen levels affect effectiveness of anti-inflammatory therapies." ScienceDaily. ScienceDaily, 2 December 2013. <www.sciencedaily.com/releases/2013/12/131202121536.htm>.
Federation of American Societies for Experimental Biology. (2013, December 2). Oxygen levels affect effectiveness of anti-inflammatory therapies. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2013/12/131202121536.htm
Federation of American Societies for Experimental Biology. "Oxygen levels affect effectiveness of anti-inflammatory therapies." ScienceDaily. www.sciencedaily.com/releases/2013/12/131202121536.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins