Featured Research

from universities, journals, and other organizations

Inflammation in prostate may reduce cancer risk

Date:
December 9, 2013
Source:
North Shore-Long Island Jewish (LIJ) Health System
Summary:
Doctors have discovered that increased inflammation in the prostate may predict reduced risk for prostate cancer.

Doctors at the North Shore-LIJ Health System have discovered that increased inflammation in the prostate may predict reduced risk for prostate cancer. The findings are published online in CANCER.

Prostate cancer is one of the most common cancers in men, with an estimated 240,000 new cases diagnosed every year - it kills approximately 30,000 men annually. The prostate is a small gland that produces fluid that nourishes and transports sperm. When the cancer is detected early while still confined to the prostate gland, there is a much better chance of successful treatment - according to the American Cancer Society, a five-year relative survival rate is 100 percent when prostate cancer is detected early and there is no sign that the cancer has spread outside of the prostate.

Previous studies have found that chronic inflammation contributes to several forms of cancer - an estimated 20 percent of adult cancers can be attributed to chronic inflammatory conditions. To evaluate if inflammation in the prostate increases the risk of cancer in the gland, Daniel Moreira, MD, a urologist at the North Shore-LIJ Health System, and his colleagues conducted a clinical trial.

They conducted a retrospective analysis of the REduction by DUtasteride of PCa Events (REDUCE) trial, including 6,238 men ages 50 to 75 who had increased prostate inflammation with a negative biopsy (no cancer). They then underwent two more biopsies - one at two years and another at four years. At both two- and four-year intervals, the doctors found that those participating in the study who had higher levels of prostate inflammation also had a lower risk of prostate cancer. These findings show that biopsies in prostates that are free of cancer and have high inflammation may indicate a lower risk for getting prostate cancer in the future.

"Because we have shown that inflammation has a predictive value, it should be routinely evaluated in prostate biopsies," said Dr. Moreira. "Also, this research shows that patients showing inflammation at an initial biopsy may be evaluated by their physician differently from with patients without inflammation at an initial biopsy given their risk of subsequent cancer detection is lower."

At the conclusion of the CANCER article, Dr. Moreira and his colleagues discuss the concept of immunosurveillance - when the immune system produces inflammation because it recognizes cancerous cells as threatening, foreign agents and eliminates them before they can become an established tumor. This concept of immunosurveillance may explain why inflammation led to a reduced risk of prostate cancer - inflammation may correlate with immunosurveillance leading to the elimination of cancerous cell. Therefore, with ongoing studies and research in monitoring and moderating inflammation, new prevention and treatment methods for prostate cancer could be discovered.


Story Source:

The above story is based on materials provided by North Shore-Long Island Jewish (LIJ) Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. Daniel M. Moreira, J. Curtis Nickel, Leah Gerber, Roberto L. Muller, Gerald L. Andriole, Ramiro Castro-Santamaria, Stephen J. Freedland. Baseline prostate inflammation is associated with a reduced risk of prostate cancer in men undergoing repeat prostate biopsy: Results from the REDUCE study. Cancer, 2013; DOI: 10.1002/cncr.28349

Cite This Page:

North Shore-Long Island Jewish (LIJ) Health System. "Inflammation in prostate may reduce cancer risk." ScienceDaily. ScienceDaily, 9 December 2013. <www.sciencedaily.com/releases/2013/12/131209105228.htm>.
North Shore-Long Island Jewish (LIJ) Health System. (2013, December 9). Inflammation in prostate may reduce cancer risk. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2013/12/131209105228.htm
North Shore-Long Island Jewish (LIJ) Health System. "Inflammation in prostate may reduce cancer risk." ScienceDaily. www.sciencedaily.com/releases/2013/12/131209105228.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins