Featured Research

from universities, journals, and other organizations

Study suggests overdiagnosis in screening for lung cancer with low-dose CT

Date:
December 9, 2013
Source:
American Medical Association (AMA)
Summary:
More than 18 percent of all lung cancers detected by low-dose computed tomography (LDCT) appeared to represent an overdiagnosis, according to a study published.

More than 18 percent of all lung cancers detected by low-dose computed tomography (LDCT) appeared to represent an overdiagnosis, according to a study published by JAMA Internal Medicine, a JAMA Network publication.

Related Articles


LDCT has been shown in recent clinical trials to be an effective screening tool in some patients, but some of the tumors it finds may be indolent (slow growing) or clinically insignificant. Overdiagnosis is the detection of a cancer with a screening test that wouldn't otherwise have become clinically apparent. It is a potential harm of screening because of the additional cost, anxiety and complications associated with unnecessary treatment, according to the study background.

Edward F. Patz Jr., M.D., of Duke University Medical Center, Durham, N.C., and colleagues examined data from the National Lung Screening Trial, which compared LDCT screening vs. chest radiography (CXR) among 53,452 people at high risk for lung cancer, to estimate overdiagnosis.

Among 1,089 lung cancers reported in the LDCT group during follow-up, the authors estimated that 18.5 percent represented an overdiagnosis. They also estimated that 22.5 percent of non-small cell lung cancer detected by LDCT represented an overdiagnosis, and that 78.9 percent of bronchioalveolar (air sacs) lung cancers detected by LDCT represented an overdiagnosis.

"In the future, once there are better biomarkers and imaging techniques to predict which individuals with a diagnosis of lung cancer will have more or less aggressive disease, treatment options can be optimized, and a mass screening program can become more valuable," the authors conclude.


Story Source:

The above story is based on materials provided by American Medical Association (AMA). Note: Materials may be edited for content and length.


Journal Reference:

  1. Edward F. Patz Jr, MD; Paul Pinsky, PhD; Constantine Gatsonis, PhD; JoRean D. Sicks, MS; Barnett S. Kramer, MD, MPH; Martin C. Tammemδgi, PhD; Caroline Chiles, MD; William C. Black, MD; Denise R. Aberle, MD. Overdiagnosis in Low-Dose Computed Tomography Screening for Lung Cancer. JAMA Internal Medicine, December 2013

Cite This Page:

American Medical Association (AMA). "Study suggests overdiagnosis in screening for lung cancer with low-dose CT." ScienceDaily. ScienceDaily, 9 December 2013. <www.sciencedaily.com/releases/2013/12/131209160708.htm>.
American Medical Association (AMA). (2013, December 9). Study suggests overdiagnosis in screening for lung cancer with low-dose CT. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2013/12/131209160708.htm
American Medical Association (AMA). "Study suggests overdiagnosis in screening for lung cancer with low-dose CT." ScienceDaily. www.sciencedaily.com/releases/2013/12/131209160708.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins