Featured Research

from universities, journals, and other organizations

Breast cancer treatment selection improved by genomic tests

Date:
December 12, 2013
Source:
Thomas Jefferson University
Summary:
Genomic testing that determines the molecular subtype of a woman’s breast cancer provides a more precise prognosis and valuable guidance about the most effective avenue of treatment.

Genomic tests that determine the molecular subtype of a woman's breast cancer provide a more precise prognosis and valuable guidance about the best treatment, according to new research led by Massimo Cristofanilli, M.D, Director of the Jefferson Breast Care Center at the Kimmel Cancer Center (KCC) and Thomas Jefferson University and Hospitals.

Dr. Cristofanilli and colleagues concluded that the genomic tests MammaPrint® and BluePrint® from Agendia help oncologists better select the most effective therapy for individual patients. In a scientific poster presentation at the San Antonio Breast Cancer Symposium (SABCS), researchers reported that molecular subtyping is superior to traditional, clinical pathology methods at classifying the nature of a woman's breast cancer and more precisely tailoring each patient's treatment.

"We found that molecular subtyping is better than traditional methods for determining the exact biological nature of a woman's cancer and therefore what is the optimal course of treatment that will provide the best outcome for her," said Dr. Cristofanilli, a noted medical oncologist. "We are now using these genomic tests and molecular subtyping in our everyday clinical practice. One advantage of this approach is that we can better identify patients who would most benefit from chemotherapy, and also those who do not need to undergo chemotherapy."

Chemotherapy risks include immediate side effects, discomfort, and long-term damage. Several studies have concluded that chemotherapy provides no real benefit for many breast cancer patients because of their cancer subtype and low risk of recurrence.

Genomic testing is part of the revolution in personalized medicine. The tests examine the activity of groups of genes within a cancer tumor, to provide a more comprehensive view of the cancer and treatment options. The four subtypes are known as Luminal A, Luminal B, Basal-type and HER2-type.

The MammaPrint test predicts how likely it is that a woman's breast cancer will recur. BluePrint then identifies the molecular subtype of her cancer and predicts tumor response to targeted therapies before and after surgery.

Study details

Breast cancer tumors have traditionally been classified using immunochemistry (IHC) and fluorescent in-situ hybridization (FISH) techniques. Dr. Cristofanilli and colleagues compared the accuracy of IHC and FISH results to MammaPrint and BluePrint, which are part of the Symphony™ panel of genomic tests.

Researchers retrospectively analyzed 325 tumor samples from breast cancer patients whose age, survival and cancer pathology (IHC/FISH) findings were known. Median follow-up on those 325 patients was 10.2 years.

The statistically significant results showed that the genomic tests reclassified 25 percent of patients into different subtypes than the subtypes determined by IHC and FISH. By comparing patients' outcomes, researchers determined the overall superiority of the genomic tests over IHC and FISH.

MammaPrint and BluePrint more accurately predicted what is known as distant metastasis free survival (DMFS) at 5 years in patients with the various subtypes, including Luminal A-type (best outcome) and triple negative tumors (worse prognosis). BluePrint revealed a different molecular diagnosis than IHC and FISH in all four subtypes of breast cancer:

• 20 out of 208 (10%) diagnosed as luminal-like by IHC/FISH were reclassified as HER2-type (n=7) and as Basal-type (n=13)

• 26 out of 52 (50%) diagnosed as HER2 positive by IHC/FISH were reclassified as Luminal A (n=5), Luminal B (n=13), and Basal-type (n=8)

• 14 out of 65 (22%) diagnosed as triple negative by IHC/FISH were reclassified as Luminal A (n=2), Luminal B (n=5) and Basal-type (n=7)

The American Cancer Society estimates that in the U.S. in 2013, 232,340 women will be diagnosed with and 39,620 women will die of breast cancer.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Breast cancer treatment selection improved by genomic tests." ScienceDaily. ScienceDaily, 12 December 2013. <www.sciencedaily.com/releases/2013/12/131212094926.htm>.
Thomas Jefferson University. (2013, December 12). Breast cancer treatment selection improved by genomic tests. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2013/12/131212094926.htm
Thomas Jefferson University. "Breast cancer treatment selection improved by genomic tests." ScienceDaily. www.sciencedaily.com/releases/2013/12/131212094926.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) — In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) — The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins