Featured Research

from universities, journals, and other organizations

Whooping cough vaccine antigen disappearing from bacteria in US

Date:
December 12, 2013
Source:
American Society for Microbiology
Summary:
Vaccines for whooping cough contain three to five protective antigens, the presence of which are critical to the vaccine's effectiveness. But one of the antigens, pertactin, which had been present in almost all isolates of Bordetella pertussis in the US as late as 2010, is now absent from more than half of them, according to a paper published.

Vaccines for whooping cough contain three to five protective antigens, the presence of which are critical to the vaccine's effectiveness. But one of the antigens, pertactin, which had been present in almost all isolates of Bordetella pertussis in the US as late as 2010, is now absent from more than half of them, according to a paper published ahead of print in Clinical and Vaccine Immunology.

"These findings tell us that there is an evolutionary advantage to lacking the protein that may have important vaccine implications," says first author Lucia C. Pawloski, of the Centers for Disease Control and Prevention, Atlanta, GA.

In the study, the researchers screened 1,300 isolates dating from 1935-2012, obtained from outbreak and surveillance studies. They used polymerase chain reaction (PCR) to identify DNA insertions into the pertactin gene, which prevents expression of that gene. The earliest such isolate was from 1994, and the next, 2010. There were 267 such isolates.

Thanks to the vaccine's other antigens, the vaccine remains effective, but that does not mean public health authorities should be complacent.

"This recent and drastic change in response to a particular vaccine antigen highlights the need to continue monitoring the circulating bacterial population to allow us to better predict future potential vaccine antigens and respond to the recent upsurge in pertussis," says Pawloski.

It is particularly important that pregnant women be vaccinated against pertussis, since infants are at greatest risk for having severe, potentially life-threatening complications from pertussis.

"After receiving this vaccine, a pregnant woman's body creates protective antibodies and passes some of them to her baby before birth," says Pawloski.

Those antibodies provide the baby with some protection that lasts until it is old enough to be vaccinated. However, fewer than 10 percent of pregnant women are being vaccinated.

Pertussis is resurgent in the United States. More than 48,000 cases were reported in 2012, up from less than 8,000 in 2000. Prevalence peaks cyclically, every three to four years, and the former number may reflect a peak, but the general trend has been strongly upward since before the millennium.

The rise in cases may be due to more sensitive and specific diagnostics, better awareness of the disease among both doctors and the general public, and waning immunity from the current acellular vaccine. Although some people do not get their children vaccinated, and such children are at least eight times more likely to get the disease than those who receive all five recommended doses they are not the driving force behind the large scale outbreaks or epidemics, says Pawloski.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. C. Pawloski, A. M. Queenan, P. K. Cassiday, A. S. Lynch, M. Harrison, W. Shang, M. M. Williams, K. E. Bowden, B. Burgos-Rivera, X. Qin, N. Messonnier, M. L. Tondella. Prevalence and molecular characterization of pertactin-deficient Bordetella pertussis in the US. Clinical and Vaccine Immunology, 2013; DOI: 10.1128/CVI.00717-13

Cite This Page:

American Society for Microbiology. "Whooping cough vaccine antigen disappearing from bacteria in US." ScienceDaily. ScienceDaily, 12 December 2013. <www.sciencedaily.com/releases/2013/12/131212123358.htm>.
American Society for Microbiology. (2013, December 12). Whooping cough vaccine antigen disappearing from bacteria in US. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/12/131212123358.htm
American Society for Microbiology. "Whooping cough vaccine antigen disappearing from bacteria in US." ScienceDaily. www.sciencedaily.com/releases/2013/12/131212123358.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins