Featured Research

from universities, journals, and other organizations

Spontaneous fusion with macrophages empowers cancer cells to spread

Date:
December 15, 2013
Source:
American Society for Cell Biology
Summary:
Researchers' findings demonstrate that spontaneous fusion of cancer cells with macrophages can profoundly and significantly impact the phenotype of tumorigenic cells, with implications for our basic understanding of cancer cell biology and the process of tumor evolution.

Cancer cells that spontaneously fuse with macrophages, the immune system's healthy scavenger cells, play a key role in the metastasis, or spread of the cancer to other areas of the body, according to research to be presented at the American Society for Cell Biology annual meeting in New Orleans.

Related Articles


The researchers, Alain Silk, Ph.D., Melissa Wong, Ph.D., and colleagues at Oregon Health & Science University (OHSU) in Portland followed the work of German pathologist Otto Aichel, who suggested in 1911 that a cancer cell under attack by a white blood cell might spontaneously fuse with that cell to produce a hybrid cell with chromosomal abnormalities that could lead to cancer.

Although Aichel's theory was dismissed by his contemporaries, recent discoveries about the broader role of cell fusion in tissue homeostasis and regeneration have revived scientific interest in his ideas. Today there is strong evidence of fusion between cancer and normal cells in human cancer, but it has not been apparent whether cell fusion could provide cancer cells with a selective advantage that enhances cancer progression.

The OSHU researchers began by confirming that cells from various types of cancer could readily and spontaneously fuse with macrophages. By intensively studying the fusion-derived cancer cells, the researchers determined that these cells exhibited enhanced adhesive strength, formed tumors more rapidly than unfused cancer cells and flourished under conditions that dramatically inhibited growth of unfused cells.

"Overall, our findings demonstrate that spontaneous fusion of cancer cells with macrophages can profoundly and significantly impact the phenotype of tumorigenic cells, with implications for our basic understanding of cancer cell biology and the process of tumor evolution," the researchers said.

As cancer progresses, tumor cells acquire new capabilities, or phenotypes. They must grow in an uncontrolled manner, leave their site of origin and become resistant to anti-cancer drugs. Previous studies on the biology of cancer have revealed that cancer progression are determined by changes to the cancer genome, epigenetics, influences from the microenvironment, exosomes and the interplay with the immune system. The OSHU research implicates the fusion of cancer cells with macrophages as a new potentiator of cancer progression.


Story Source:

The above story is based on materials provided by American Society for Cell Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Cell Biology. "Spontaneous fusion with macrophages empowers cancer cells to spread." ScienceDaily. ScienceDaily, 15 December 2013. <www.sciencedaily.com/releases/2013/12/131215160854.htm>.
American Society for Cell Biology. (2013, December 15). Spontaneous fusion with macrophages empowers cancer cells to spread. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2013/12/131215160854.htm
American Society for Cell Biology. "Spontaneous fusion with macrophages empowers cancer cells to spread." ScienceDaily. www.sciencedaily.com/releases/2013/12/131215160854.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins