Featured Research

from universities, journals, and other organizations

BCG vaccine more effective than previously thought

Date:
December 19, 2013
Source:
London School of Hygiene & Tropical Medicine
Summary:
The BCG vaccine has been found to be more effective against the most common form of tuberculosis than previously thought, according to a systematic review.

The BCG vaccine has been found to be more effective against the most common form of tuberculosis than previously thought, according to a new study in Clinical Infectious Diseases.

Related Articles


Bacillus Calmette Guιrin (BCG) vaccine is included in the childhood vaccination programme of many countries, and is the only licensed vaccine against tuberculosis (TB). However, it has previously been thought to only be effective against the less common forms of the disease that occur away from the lungs. Its efficacy against pulmonary TB, found in the lungs and by far the greatest burden of TB, has varied widely depending on location, ranging from 0% in South India to 80% in the UK.

In order to better understand the reason behind this variability, researchers led by the London School of Hygiene & Tropical Medicine conducted a systematic review of global literature on all reported BCG trials across 10 medical electronic databases, looking at the factors affecting its level of protection against pulmonary TB.

The research shows for the first time that the BCG vaccine is actually highly protective against pulmonary TB in all parts of the world, including significant protection when administered in the tropics.

The main reason for the apparent variation in protection against disease seen in previous studies was found to be due to prior infection reducing the efficacy of the vaccine. BCG vaccination for those with no history of prior TB infection, including young infants, showed a much higher efficacy against pulmonary TB.

The study therefore highlights a new role for BCG in fighting pulmonary TB, a need for early vaccination, and further suggests that any new TB vaccine based on BCG will also need to be administered before infection has occurred.

Lead author Dr Punam Mangtani, Clinical Senior Lecturer in Epidemiology at the London School of Hygiene & Tropical Medicine, said: "This research corrects a longstanding misconception that BCG is ineffective against pulmonary disease, and confirms its importance in controlling the major burden from TB and main source of transmission in all settings. Now that we know previous infection can lower the protection provided by the vaccine, it is important that BCG is given as early as possible in a person's life, and ideally immediately after birth."


Story Source:

The above story is based on materials provided by London School of Hygiene & Tropical Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. P. Mangtani, I. Abubakar, C. Ariti, R. Beynon, L. Pimpin, P. E. M. Fine, L. C. Rodrigues, P. G. Smith, M. Lipman, P. F. Whiting, J. A. Sterne. Protection by BCG against tuberculosis: a systematic review of randomised controlled trials. Clinical Infectious Diseases, 2013; DOI: 10.1093/cid/cit790

Cite This Page:

London School of Hygiene & Tropical Medicine. "BCG vaccine more effective than previously thought." ScienceDaily. ScienceDaily, 19 December 2013. <www.sciencedaily.com/releases/2013/12/131219131149.htm>.
London School of Hygiene & Tropical Medicine. (2013, December 19). BCG vaccine more effective than previously thought. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2013/12/131219131149.htm
London School of Hygiene & Tropical Medicine. "BCG vaccine more effective than previously thought." ScienceDaily. www.sciencedaily.com/releases/2013/12/131219131149.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) — A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) — Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) — A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) — Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins