Featured Research

from universities, journals, and other organizations

Nicotine exploits COPI to foster addiction

Date:
December 30, 2013
Source:
Rockefeller University Press
Summary:
Study helps explain how nicotine exploits the body’s cellular machinery to promote addiction. The findings could lead to new therapies to help people quit smoking.

A study in The Journal of General Physiology helps explain how nicotine exploits the body's cellular machinery to promote addiction. The findings could lead to new therapies to help people quit smoking.

Related Articles


According to the Center for Disease Control and Prevention, tobacco accounts for the greatest number of preventable deaths worldwide by any single agent. Nicotine, the active ingredient of tobacco, activates receptors known as nAChRs and, remarkably , unlike most other drugs of abuse, it acts as a "pharmacological chaperone" to stabilize assembly of its receptors within the Endoplasmic Reticulum (ER) and increase their abundance at the cell surface (up-regulation). Up-regulation of nAChRs plays a major role in nicotine addiction and, possibly, in the decreased susceptibility of smokers to Parkinson's disease.

Receptors containing an ∝6 subunit (∝6* nAChRs) are abundant in several specific brain regions. Researchers from the California Institute of Technology in Pasadena used mice expressing ∝6 labeled with a fluorescent protein to show that exposure to nicotine -- at a level comparable to that in human smokers -- up-regulated∝6* nAChRs in these areas of the brain.

Unexpectedly, the researchers discovered that nicotine's ability to up-regulate ∝6* nAChRs relied on the retrograde transport of ∝6* nAChRs back from the Golgi to the ER by COPI-coated vesicles. The authors believe that Golgi-ER cycling (involving COPI vesicles) may be a common mechanism for up-regulation of other nAChRs by nicotine. Manipulation of this process could therefore help form new strategies for smoking cessation and neuroprotection against Parkinson's disease.


Story Source:

The above story is based on materials provided by Rockefeller University Press. The original article was written by Henry A. Lester. Note: Materials may be edited for content and length.


Journal References:

  1. B. J. Henderson, R. Srinivasan, W. A. Nichols, C. N. Dilworth, D. F. Gutierrez, E. D. W. Mackey, S. McKinney, R. M. Drenan, C. I. Richards, H. A. Lester. Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. The Journal of General Physiology, 2013; 143 (1): 51 DOI: 10.1085/jgp.201311102
  2. R. Anand. COPI polices nicotine-mediated up-regulation of nicotinic receptors. The Journal of General Physiology, 2013; 143 (1): 49 DOI: 10.1085/jgp.201311136

Cite This Page:

Rockefeller University Press. "Nicotine exploits COPI to foster addiction." ScienceDaily. ScienceDaily, 30 December 2013. <www.sciencedaily.com/releases/2013/12/131230134943.htm>.
Rockefeller University Press. (2013, December 30). Nicotine exploits COPI to foster addiction. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2013/12/131230134943.htm
Rockefeller University Press. "Nicotine exploits COPI to foster addiction." ScienceDaily. www.sciencedaily.com/releases/2013/12/131230134943.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Former NFL Players Donate Brains to Science

Former NFL Players Donate Brains to Science

Reuters - US Online Video (Mar. 3, 2015) Super Bowl champions Sidney Rice and Steve Weatherford donate their brains, post-mortem, to scientific research into repetitive brain trauma. Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Alzheimer's Protein Plaque Found In 20-Year-Olds

Alzheimer's Protein Plaque Found In 20-Year-Olds

Newsy (Mar. 3, 2015) Researchers found an abnormal protein associated with Alzheimer&apos;s disease in the brains of 20-year-olds. Video provided by Newsy
Powered by NewsLook.com
This Nasal Treatment Could Help Ease Migraine Pain

This Nasal Treatment Could Help Ease Migraine Pain

Newsy (Mar. 2, 2015) Researchers gave lidocaine to 112 patients, and about 88 percent of the subjects said they needed less migraine-relief medicine the next day. Video provided by Newsy
Powered by NewsLook.com
How Facebook Use Can Lead To Depression

How Facebook Use Can Lead To Depression

Newsy (Mar. 1, 2015) Margaret Duffy of the University of Missouri talks about her study on the social network and the envy and depression that Facebook use can cause. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins