Featured Research

from universities, journals, and other organizations

Brief fever common in kids given influenza, pneumococcal vaccines together

Date:
January 6, 2014
Source:
Columbia University Medical Center
Summary:
Giving young children the influenza and pneumococcal vaccines together appears to increase their risk of fever, according to a study that looked at children 6–23 months old.

Giving young children the influenza and pneumococcal vaccines together appears to increase their risk of fever, according to a study led by researchers from Columbia University Medical Center (CUMC) and the Centers for Disease Control and Prevention (CDC). However, the fever was brief, and medical care was sought for few children, supporting the routine immunization schedule for these vaccines, including the recommendation to administer them simultaneously. The study, which looked at children 6-23 months old, was published online on Jan. 6, 2014, in JAMA Pediatrics.

Public health experts agree that timely immunizations are an important means of protection against serious diseases and infections for people of all ages. The CDC and other medical professional organizations often recommend giving the influenza and pneumococcal vaccines at the same visit, if both are due -- both to prevent getting influenza or other infections between visits and to avoid a possible delay in vaccinations due to difficulty returning to the clinic (because of work schedules or other competing priorities).

"While our data suggest that giving children the influenza and pneumococcal vaccines together at the same visit increases the risk of fever, compared with getting only one of the vaccines at the visit, these findings should be viewed in context of the benefit of vaccines to prevent serious illness in young children, as well as the recognized need to increase vaccination rates overall," said study first author Melissa S. Stockwell, MD, MPH, Florence Irving Assistant Professor of Pediatrics and Population and Family Health at Columbia College of Physicians and Surgeons, with a joint appointment at Columbia's Mailman School of Public Health.

"Parents should be made aware that their child might develop a fever following simultaneous influenza and pneumococcal vaccinations -- but that the benefits of these vaccines outweigh the risk of fever and, in most cases, the fever will be brief," said Dr. Stockwell. "For the small group of children who must avoid fever, these findings provide important information for clinicians and parents."

The study followed 530 children recruited during the 2011-2012 influenza season from three community-based clinics affiliated with NewYork-Presbyterian /Columbia University Medical Center, who were receiving their usual vaccinations.

Parents received a text message on the night of vaccination and the seven subsequent nights, asking them to report the highest temperature in their child since the temperature had last been taken. Messages were sent in English or Spanish, based on parent preference. More than 90 percent of families who were confirmed to have received a text message on the day of or day after vaccination responded to the message, and 85 percent of parents reported being very satisfied with their participation in the study.

After controlling for age and other factors, among children who received simultaneous influenza and pneumococcal vaccines, about a third (37.6 percent) had a fever of 100.4 F (38 C) or higher on the day of or day after vaccination, compared with children who received only the pneumococcal (9.5 percent) or only the influenza (7.5 percent) vaccine. In other words, children receiving the influenza and pneumococcal vaccine together were about three times as likely to have a fever on the day of or day after vaccination, compared with children who received either vaccine alone. There were no differences among the groups in rates of fever in the 2-7 days after vaccination.

Overall, for every 100 children there were an additional 20-23 cases of temperatures of 100.4 F (38 C) or higher in children with simultaneous influenza and pneumococcal vaccination, compared with those who received only one of the vaccines. There were also 15 additional cases of temperatures of 102.2 F (39 C) or higher in children who received both vaccines, compared with the influenza vaccine alone, but not compared with the pneumococcal vaccine.

"We are committed to making sure that the safety of vaccines is continuously monitored and to better understanding any potential risks associated with vaccination," said Claudia Vellozzi, MD, MPH, deputy director of the Immunization Safety Office at the Centers for Disease Control and Prevention, and the study's senior author. "This study also demonstrates how novel approaches, like text messaging to assess fever following vaccination, can be used to enhance vaccine-safety monitoring."

"Before our study, text messaging had not been used to address a specific vaccine-safety question," said Dr. Stockwell, who is also medical director of the NewYork-Presbyterian Hospital Immunization Registry (EzVac) and a pediatrician at NewYork-Presbyterian/Morgan Stanley Children's Hospital. "Unlike conventional surveillance methods, such as paper or phone, in which reporting may be delayed, text messaging appears to enable rapid, large-scale data collection."

"These findings are a first step; the next step is to figure out if there are any measurable biological markers, such as findings in a blood sample, that are associated with increased risk of fever after vaccination," said study co-author Philip S. LaRussa, MD, professor of pediatrics at CUMC and specialist in pediatric infectious diseases at NewYork-Presbyterian/Columbia.


Story Source:

The above story is based on materials provided by Columbia University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Karen Broder, MD; Paige Lewis, MSPH; Devindra Sharma, MSN, MPH; Nadira Fernandez, MD; Angela Barrett; Jose Sosa, MD; Melissa S. Stockwell. Risk of Fever After Pediatric Trivalent Inactivated Influenza Vaccine and 13-Valent Pneumococcal Conjugate Vaccine. Jama Pediatrics, January 2014

Cite This Page:

Columbia University Medical Center. "Brief fever common in kids given influenza, pneumococcal vaccines together." ScienceDaily. ScienceDaily, 6 January 2014. <www.sciencedaily.com/releases/2014/01/140106190048.htm>.
Columbia University Medical Center. (2014, January 6). Brief fever common in kids given influenza, pneumococcal vaccines together. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2014/01/140106190048.htm
Columbia University Medical Center. "Brief fever common in kids given influenza, pneumococcal vaccines together." ScienceDaily. www.sciencedaily.com/releases/2014/01/140106190048.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins