Featured Research

from universities, journals, and other organizations

Higher risk of birth problems after assisted conception

Date:
January 9, 2014
Source:
University of Adelaide
Summary:
A study has shown that the risk of serious complications such as stillbirth, preterm birth, low birth weight and neonatal death is around twice as high for babies conceived by assisted reproductive therapies compared with naturally conceived babies.

The risk of serious complications such as stillbirth, preterm birth, low birth weight and neonatal death is around twice as high for babies conceived by assisted reproductive therapies compared with naturally conceived babies.
Credit: Sergey Bogdanov / Fotolia

A University of Adelaide study has shown that the risk of serious complications such as stillbirth, preterm birth, low birth weight and neonatal death is around twice as high for babies conceived by assisted reproductive therapies compared with naturally conceived babies.

Related Articles


In the most comprehensive study of its kind in the world, researchers from the University's Robinson Institute have compared the outcomes of more than 300,000 births in South Australia over a 17-year period. This included more than 4300 births from assisted reproduction.

They compared adverse birth events related to all forms of available treatment, including in-vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), ovulation induction, and cryopreservation of embryos.

The results are published online today in the journal PLOS ONE.

"Compared with spontaneous conceptions in couples with no record of infertility, singleton babies from assisted conception were almost twice as likely to be stillborn, more than twice as likely to be preterm, almost three times as likely to have very low birth weight, and twice as likely to die within the first 28 days of birth," says the study leader, Professor Michael Davies from the University of Adelaide's Robinson Institute.

"These outcomes varied depending on the type of assisted conception used. Very low and low birth weight, very preterm and preterm birth, and neonatal death were markedly more common in births from IVF and, to a lesser degree, in births from ICSI," he says.

"Using frozen embryos eliminated all significant adverse outcomes associated with ICSI but not with IVF. However, frozen embryos were also associated with increased risk of macrosomia (big baby syndrome) for IVF and ICSI babies."

Professor Davies says the study confirms related work in Europe and Australia showing that infertility treatment is associated with adverse outcomes for newborn babies.

"More research is now urgently needed into longer term follow-up of those who have experienced comprehensive perinatal disadvantage," he says. "Our studies also need to be expanded to include more recent years of treatment, as the technology has been undergoing continual innovation, which may influence the associated risks."

This is also the first study to make a comparison with pregnancies in women diagnosed with infertility, but who never received intensive treatment.

"Women in this group who eventually conceived without the help of invasive assisted reproduction gave birth to babies who were nine times more likely to have very low birth weight, seven times more likely to be very preterm, and almost seven times more likely to die within the first 28 days of birth. This may be due to the underlying medical conditions related to their infertility, or the use of fertility medications or therapies that are not recorded," Professor Davies says.


Story Source:

The above story is based on materials provided by University of Adelaide. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jennifer L. Marino, Vivienne M. Moore, Kristyn J. Willson, Alice Rumbold, Melissa J. Whitrow, Lynne C. Giles, Michael J. Davies. Perinatal Outcomes by Mode of Assisted Conception and Sub-Fertility in an Australian Data Linkage Cohort. PLoS ONE, 2014; 9 (1): e80398 DOI: 10.1371/journal.pone.0080398

Cite This Page:

University of Adelaide. "Higher risk of birth problems after assisted conception." ScienceDaily. ScienceDaily, 9 January 2014. <www.sciencedaily.com/releases/2014/01/140109003800.htm>.
University of Adelaide. (2014, January 9). Higher risk of birth problems after assisted conception. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2014/01/140109003800.htm
University of Adelaide. "Higher risk of birth problems after assisted conception." ScienceDaily. www.sciencedaily.com/releases/2014/01/140109003800.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins