Featured Research

from universities, journals, and other organizations

Fathers' diet, bodyweight, health at conception may contribute to obesity in offspring

Date:
January 16, 2014
Source:
Federation of American Societies for Experimental Biology
Summary:
Research involving rats suggests a biological link between paternal diet, bodyweight and health at the time of conception and the health of his offspring. In a new research report, scientists show that if male rats ate a high fat diet, had diabetes and were obese, their offspring had altered gene expression in two important metabolic tissues -- pancreas and fat (even though they were not yet obese).

Research involving rats suggests that there is a biological link between paternal diet, bodyweight and health at the time of conception and the health of his offspring. In a new research report published online in The FASEB Journal, scientists show that if male rats ate a high fat diet, had diabetes and were obese, their offspring had altered gene expression in two important metabolic tissues--pancreas and fat (even though they were not yet obese). This altered gene expression may increase the risk of future obesity and premature aging. Other genes that were affected include markers of premature aging, cancer, and chronic degenerative disease.

Related Articles


"While scientists have focused on how the maternal diet affects children's health, this study is part of exciting new research exploring the impact of paternal diet on offspring risk of obesity," said Margaret Morris, Ph.D., a researcher involved in the work from the Pharmacology School of Medical Sciences at the University of New South Wales in Sydney, Australia. "The fact that similar gene markers were affected in pancreas and fat tissue tells us that some of the same pathways are being influenced, possibly from the earliest stages of life. It will be important to follow up these findings, and to learn more about when and how to intervene to reduce the impact of poor paternal metabolic health on offspring."

To make this discovery, Morris and colleagues used two groups of male rats, one of which was obese and diabetic and fed a high-fat diet; and the other was lean and healthy and fed a normal diet. The two groups of males were mated with lean female rats, and researchers examined their female offspring. Those who were born from obese fathers on a high-fat diet, showed a poor ability to respond to a glucose challenge, even while consuming a healthy diet. Specifically, the offspring of the obese rats showed gene expression changes in pancreatic islets, which are responsible for producing insulin to control blood glucose and the fat tissue of their female offspring.

"For a long time, we've known that the nutrition and health status of women who are pregnant or who want to get pregnant is critical to the health of her offspring, and we've also suspected that the same is true for fathers to a lesser degree," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This report is the first step in understanding exactly how the nutrition and health of fathers affects his children, for better or worse."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. S.-F. Ng, R. C. Y. Lin, C. A. Maloney, N. A. Youngson, J. A. Owens, M. J. Morris. Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring. The FASEB Journal, 2014; DOI: 10.1096/fj.13-244046

Cite This Page:

Federation of American Societies for Experimental Biology. "Fathers' diet, bodyweight, health at conception may contribute to obesity in offspring." ScienceDaily. ScienceDaily, 16 January 2014. <www.sciencedaily.com/releases/2014/01/140116162212.htm>.
Federation of American Societies for Experimental Biology. (2014, January 16). Fathers' diet, bodyweight, health at conception may contribute to obesity in offspring. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2014/01/140116162212.htm
Federation of American Societies for Experimental Biology. "Fathers' diet, bodyweight, health at conception may contribute to obesity in offspring." ScienceDaily. www.sciencedaily.com/releases/2014/01/140116162212.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Hikers Rescued After Fall from Oregon Mountain

Hikers Rescued After Fall from Oregon Mountain

AP (Feb. 1, 2015) Two climbers who were hurt in a fall on Mount Hood are now being treated for their injuries. Rescue officials say they were airlifted off the mountain Saturday afternoon by an Oregon National Guard helicopter. (Feb. 2) Video provided by AP
Powered by NewsLook.com
Smart Glasses Augment Reality to Help Visually Impaired

Smart Glasses Augment Reality to Help Visually Impaired

Reuters - Innovations Video Online (Feb. 1, 2015) New augmented reality smart glasses developed by researchers at Oxford University can help people with visual impairments improve their vision by providing depth-based feedback, allowing users to "see" better. Joel Flynn reports. Video provided by Reuters
Powered by NewsLook.com
Flu Season Hitting Elderly Hard

Flu Season Hitting Elderly Hard

Reuters - US Online Video (Jan. 31, 2015) The CDC says this year&apos;s flu season is hitting people 65 years of age and older especially hard. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins